Title |
Fiber intake modulates the association of alcohol intake with breast cancer
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Published in |
International Journal of Cancer, November 2016
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DOI | 10.1002/ijc.30415 |
Pubmed ID | |
Authors |
Isabelle Romieu, Pietro Ferrari, Veronique Chajès, Jordi de Batlle, Carine Biessy, Chiara Scoccianti, Laure Dossus, Marie Christine Boutron, Nadia Bastide, Kim Overvad, Anja Olsen, Anne Tjønneland, Rudolf Kaaks, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario Tumino, Paolo Vineis, Salvatore Panico, H. B(as) Bueno‐de‐Mesquita, Carla H. Gils, Petra H. Peeters, Eiliv Lund, Guri Skeie, Elisabete Weiderpass, J. Ramón Quirós, María‐Dolores Chirlaque, Eva Ardanaz, María‐José Sánchez, Eric J. Duell, Pilar Amiano Etxezarreta, Signe Borgquist, Göran Hallmans, Ingegerd Johansson, Lena Maria Nilsson, Kay‐Tee Khaw, Nick Wareham, Timothy J. Key, Ruth C. Travis, Neil Murphy, Petra A. Wark, Elio Riboli |
Abstract |
Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and breast cancer using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive breast cancer according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10g/day of alcohol intake was 1.06 (1.03-1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p=0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. This article is protected by copyright. All rights reserved. © 2014 Wiley Periodicals, Inc. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 6 | 29% |
United States | 4 | 19% |
Brazil | 1 | 5% |
Venezuela, Bolivarian Republic of | 1 | 5% |
New Zealand | 1 | 5% |
Unknown | 8 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 19 | 90% |
Scientists | 2 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 17% |
Researcher | 9 | 14% |
Student > Bachelor | 7 | 11% |
Student > Ph. D. Student | 6 | 9% |
Professor | 5 | 8% |
Other | 10 | 16% |
Unknown | 16 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 30% |
Nursing and Health Professions | 7 | 11% |
Agricultural and Biological Sciences | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Environmental Science | 3 | 5% |
Other | 11 | 17% |
Unknown | 18 | 28% |