| Title |
Effects of raloxifene on lipid and bone metabolism in postmenopausal women with type 2 diabetes
|
|---|---|
| Published in |
Journal of Bone and Mineral Metabolism, August 2012
|
| DOI | 10.1007/s00774-012-0379-8 |
| Pubmed ID | |
| Authors |
Hiroko Mori, Yosuke Okada, Hirofumi Kishikawa, Nobuo Inokuchi, Hidekatsu Sugimoto, Yoshiya Tanaka |
| Abstract |
Evidence suggests that bone quality is poorer and fracture risk is higher in patients with diabetes, even those with normal bone mineral density. The aim of this study was to determine the effects of raloxifene on lipid, bone, and glucose metabolism in postmenopausal women with type 2 diabetes. The study subjects (144 postmenopausal women aged less than 80 years with type 2 diabetes) were randomly assigned into three groups: no medication, alfacalcidol 1 μg/day, or raloxifene hydrochloride 60 mg/day. The primary endpoint was the change in LDL-C at 6 months. Raloxifene significantly decreased the levels of bone metabolism markers NTX and BAP at 6 months in patients with diabetes. The primary endpoint, LDL-C at 6 months, was significantly lower in the raloxifene group than in the other two groups. However, percent changes in HDL-C were not significantly different among the three groups. Although glucose metabolism was unaffected, homocysteine, a bone quality marker, was significantly decreased at 6 months in the raloxifene group. The percent improvement in LDL-C did not correlate with percent improvement in any bone metabolism or bone quality markers. Raloxifene, unlike estrogen, improved LDL-C and decreased homocysteine, indicating that raloxifene can potentially improve LDL-C as well as bone quality in postmenopausal women with type 2 diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 4% |
| Unknown | 26 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 19% |
| Student > Ph. D. Student | 5 | 19% |
| Student > Master | 3 | 11% |
| Other | 2 | 7% |
| Researcher | 2 | 7% |
| Other | 4 | 15% |
| Unknown | 6 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 44% |
| Social Sciences | 2 | 7% |
| Arts and Humanities | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Unspecified | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 8 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2013.
All research outputs
#19,237,853
of 23,842,189 outputs
Outputs from Journal of Bone and Mineral Metabolism
#488
of 787 outputs
Outputs of similar age
#129,660
of 168,020 outputs
Outputs of similar age from Journal of Bone and Mineral Metabolism
#3
of 5 outputs
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So far Altmetric has tracked 787 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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