| Title |
Wax-incorporated Emulsion Gel Beads of Calcium Pectinate for Intragastric Floating Drug Delivery
|
|---|---|
| Published in |
AAPS PharmSciTech, May 2008
|
| DOI | 10.1208/s12249-008-9082-4 |
| Pubmed ID | |
| Authors |
Pornsak Sriamornsak, Panida Asavapichayont, Jurairat Nunthanid, Manee Luangtana-anan, Sontaya Limmatvapirat, Suchada Piriyaprasarth |
| Abstract |
The purpose of this study was to prepare wax-incorporated pectin-based emulsion gel beads using a modified emulsion-gelation method. The waxes in pectin-olive oil mixtures containing a model drug, metronidazole, were hot-melted, homogenized and then extruded into calcium chloride solution. The beads formed were separated, washed with distilled water and dried for 12 h. The influence of various types and amounts of wax on floating and drug release behavior of emulsion gel beads of calcium pectinate was investigated. The drug-loaded gel beads were found to float on simulated gastric fluid if the sufficient amount of oil was used. Incorporation of wax into the emulsion gel beads affected the drug release. Water-soluble wax (i.e. polyethylene glycol) increased the drug release while other water-insoluble waxes (i.e. glyceryl monostearate, stearyl alcohol, carnauba wax, spermaceti wax and white wax) significantly retarded the drug release. Different waxes had a slight effect on the drug release. However, the increased amount of incorporated wax in the formulations significantly sustained the drug release while the beads remained floating. The results suggest that wax-incorporated emulsion gel beads could be used as a carrier for intragastric floating drug delivery. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Romania | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 15% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 5 | 11% |
| Professor | 5 | 11% |
| Professor > Associate Professor | 4 | 9% |
| Other | 9 | 19% |
| Unknown | 12 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 28% |
| Agricultural and Biological Sciences | 8 | 17% |
| Medicine and Dentistry | 6 | 13% |
| Engineering | 2 | 4% |
| Chemistry | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 14 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2013.
All research outputs
#14,742,867
of 22,693,205 outputs
Outputs from AAPS PharmSciTech
#1,013
of 1,466 outputs
Outputs of similar age
#65,990
of 78,614 outputs
Outputs of similar age from AAPS PharmSciTech
#14
of 16 outputs
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