Title |
Caveolae as plasma membrane sensors, protectors and organizers
|
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Published in |
Nature Reviews Molecular Cell Biology, January 2013
|
DOI | 10.1038/nrm3512 |
Pubmed ID | |
Authors |
Robert G. Parton, Miguel A. del Pozo |
Abstract |
Caveolae are submicroscopic, plasma membrane pits that are abundant in many mammalian cell types. The past few years have seen a quantum leap in our understanding of the formation, dynamics and functions of these enigmatic structures. Caveolae have now emerged as vital plasma membrane sensors that can respond to plasma membrane stresses and remodel the extracellular environment. Caveolae at the plasma membrane can be removed by endocytosis to regulate their surface density or can be disassembled and their structural components degraded. Coat proteins, called cavins, work together with caveolins to regulate the formation of caveolae but also have the potential to dynamically transmit signals that originate in caveolae to various cellular destinations. The importance of caveolae as protective elements in the plasma membrane, and as membrane organizers and sensors, is highlighted by links between caveolae dysfunction and human diseases, including muscular dystrophies and cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
United Kingdom | 1 | 33% |
Mexico | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 8 | 1% |
United Kingdom | 5 | <1% |
Germany | 4 | <1% |
Portugal | 3 | <1% |
Spain | 3 | <1% |
Canada | 3 | <1% |
France | 2 | <1% |
Sweden | 2 | <1% |
Italy | 2 | <1% |
Other | 12 | 2% |
Unknown | 743 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 152 | 19% |
Student > Bachelor | 80 | 10% |
Student > Master | 73 | 9% |
Student > Doctoral Student | 47 | 6% |
Other | 110 | 14% |
Unknown | 109 | 14% |
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Biochemistry, Genetics and Molecular Biology | 210 | 27% |
Medicine and Dentistry | 47 | 6% |
Neuroscience | 24 | 3% |
Chemistry | 22 | 3% |
Other | 97 | 12% |
Unknown | 145 | 18% |