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Predictors of significant coronary artery disease in atrial fibrillation: Are cardiac troponins a useful measure

Overview of attention for article published in International Journal of Cardiology, August 2016
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Title
Predictors of significant coronary artery disease in atrial fibrillation: Are cardiac troponins a useful measure
Published in
International Journal of Cardiology, August 2016
DOI 10.1016/j.ijcard.2016.08.267
Pubmed ID
Authors

Alaa Alghamry, Joseph Hanna, Anita Pelecanos, Stephen Kyranis, Vinod Khelgi, Peter O'Rourke, Oran Carroll, Cassie Oxenford, Swetha Rangaswamaiah, Christopher Tan

Abstract

Cardiac Troponin I (cTnI) is frequently measured in patients presenting with symptomatic atrial fibrillation (AF). The significance of elevated cTnI levels in this patient cohort is unclear. We investigated the value of cTnI elevation in this setting and whether it is predictive for significant coronary artery disease (sCAD). We conducted a retrospective, single-center, case-control study of 231 patients who presented with symptomatic AF to The Prince Charles Hospital emergency department, Brisbane, Australia between 2006 and 2014. Patients who underwent serial cTnI testing and assessment for CAD were included. Clinical variables that are known to predict CAD and could potentially predict cTnI elevation were collected. Binary logistic regression was performed to identify predictors of sCAD and cTnI elevation. Cardiac Troponin I elevation above standard cut off was not predictive for sCAD after adjustment for other predictors (OR 1.62, 95% CI 0.79-3.32. p=0.19). However, the highest cTnI concentration value (cTnI peak) was predictive for sCAD (OR 2.02, 95% CI 1.02-3.97, p=0.04). Dyspnea on presentation (OR 4.52, 95% CI 1.87-10.91, p=0.001), known coronary artery disease (OR 3.44, 95% CI 1.42-8.32, p=0.006), and ST depression on the initial electrocardiogram (OR 2.57, 95% CI 1.11-5.97, p=0.028) predicted sCAD in our cohort, while heart rate on initial presentation was inversely correlated with sCAD (OR 0.99, 95% CI 0.971-1.00, p=0.034). Troponin elevation is common in patients presenting to hospital with acute symptomatic AF and it is not a reliable indicator for underlying sCAD in this patient cohort. However, cTnI peak was a predictor of significant coronary artery disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 16%
Other 3 12%
Professor 3 12%
Student > Doctoral Student 2 8%
Student > Bachelor 2 8%
Other 5 20%
Unknown 6 24%
Readers by discipline Count As %
Medicine and Dentistry 12 48%
Nursing and Health Professions 2 8%
Neuroscience 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Unknown 9 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2016.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from International Journal of Cardiology
#5,409
of 7,535 outputs
Outputs of similar age
#261,879
of 354,571 outputs
Outputs of similar age from International Journal of Cardiology
#154
of 263 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,535 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,571 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 263 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.