| Title |
Aging asymmetry: systematic survey of changes in age-related biomarkers in the annual fish Nothobranchius guentheri
|
|---|---|
| Published in |
Fish Physiology and Biochemistry, September 2016
|
| DOI | 10.1007/s10695-016-0288-1 |
| Pubmed ID | |
| Authors |
Yuan Dong, Pengfei Cui, Zhijian Li, Shicui Zhang |
| Abstract |
Aging asymmetry is the observation that different tissues age in different ways and at different rates. This has not been assessed in a single organism using multiple biomarkers of aging. Here we clearly demonstrated that the levels of protein oxidation and lipid peroxidation as well as CAT, SOD and GPX activities all showed a tissue-dependent change with advancing age; and DNA repair ability, as revealed by the expression of ercc1 and its protein levels, also exhibited a tissue-specific variation with age. We also found that protein oxidation and lipid peroxidation levels remained relatively stable in the liver, intestine, skin and testis as well as in the brain, eye and heart of young, adult and aged fishes; SOD and GPX activities displayed little variation in the intestine, eye and skin as well as in the brain and skin of young, adult and aged fishes; and low and stable expression of ercc1 was observed in the spleen, eye and heart of young, adult and aged fishes. Collectively, these results indicate that aging is tissue specific and asymmetric in N. guentheri. The observation of aging asymmetry may have practical implications for the application of non-intrusion intervention approaches to prolong lifespan. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 27% |
| Lecturer > Senior Lecturer | 2 | 9% |
| Student > Master | 2 | 9% |
| Student > Ph. D. Student | 2 | 9% |
| Student > Doctoral Student | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 6 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 23% |
| Biochemistry, Genetics and Molecular Biology | 4 | 18% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Environmental Science | 1 | 5% |
| Neuroscience | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 9 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2016.
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#20,341,859
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Outputs from Fish Physiology and Biochemistry
#605
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#283,166
of 325,670 outputs
Outputs of similar age from Fish Physiology and Biochemistry
#5
of 7 outputs
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