| Title |
New Topoisomerase I mutations are associated with resistance to camptothecin
|
|---|---|
| Published in |
Molecular Cancer, May 2011
|
| DOI | 10.1186/1476-4598-10-64 |
| Pubmed ID | |
| Authors |
Céline Gongora, Nadia Vezzio-Vie, Sandie Tuduri, Vincent Denis, Annick Causse, Céline Auzanneau, Gwenaëlle Collod-Beroud, Arnaud Coquelle, Philippe Pasero, Philippe Pourquier, Pierre Martineau, Maguy Del Rio |
| Abstract |
Topoisomerase I (TOP1) is a nuclear enzyme that catalyzes the relaxation of supercoiled DNA during DNA replication and transcription. TOP1 is the molecular target of camptothecin and related drugs such as irinotecan and SN38 (irinotecan's active metabolite). Irinotecan is widely used as an anti-cancer agent in the treatment of metastatic colon cancer. However, its efficacy is often limited by the development of resistance. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | 4% |
| United States | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 66 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 27% |
| Student > Ph. D. Student | 15 | 21% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 7 | 10% |
| Professor | 5 | 7% |
| Other | 7 | 10% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 32% |
| Biochemistry, Genetics and Molecular Biology | 22 | 31% |
| Medicine and Dentistry | 10 | 14% |
| Chemistry | 2 | 3% |
| Nursing and Health Professions | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 11 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2013.
All research outputs
#20,178,948
of 22,693,205 outputs
Outputs from Molecular Cancer
#1,473
of 1,715 outputs
Outputs of similar age
#104,160
of 112,047 outputs
Outputs of similar age from Molecular Cancer
#14
of 15 outputs
Altmetric has tracked 22,693,205 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,715 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.