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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses
|
|---|---|
| Published in |
Cancer Cell, September 2016
|
| DOI | 10.1016/j.ccell.2016.06.025 |
| Pubmed ID | |
| Authors |
Arabella Young, Shin Foong Ngiow, Deborah S. Barkauskas, Erin Sult, Carl Hay, Stephen J. Blake, Qihui Huang, Jing Liu, Kazuyoshi Takeda, Michele W.L. Teng, Kris Sachsenmeier, Mark J. Smyth |
| Abstract |
Preclinical studies targeting the adenosinergic pathway have gained much attention for their clinical potential in overcoming tumor-induced immunosuppression. Here, we have identified that co-blockade of the ectonucleotidase that generates adenosine CD73 and the A2A adenosine receptor (A2AR) that mediates adenosine signaling in leuokocytes, by using compound gene-targeted mice or therapeutics that target these molecules, limits tumor initiation, growth, and metastasis. This tumor control requires effector lymphocytes and interferon-γ, while antibodies targeting CD73 promote an optimal therapeutic response in vivo when engaging activating Fc receptors. In a two-way mixed leukocyte reaction using a fully human anti-CD73, we demonstrated that Fc receptor binding augmented the production of proinflammatory cytokines. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 15% |
| France | 1 | 8% |
| Israel | 1 | 8% |
| Unknown | 9 | 69% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Scientists | 3 | 23% |
Mendeley readers
The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 288 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 65 | 22% |
| Student > Ph. D. Student | 46 | 16% |
| Other | 23 | 8% |
| Student > Master | 23 | 8% |
| Student > Doctoral Student | 19 | 7% |
| Other | 43 | 15% |
| Unknown | 73 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 54 | 18% |
| Agricultural and Biological Sciences | 43 | 15% |
| Immunology and Microbiology | 41 | 14% |
| Medicine and Dentistry | 34 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 5% |
| Other | 26 | 9% |
| Unknown | 80 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2023.
All research outputs
#2,329,745
of 25,373,627 outputs
Outputs from Cancer Cell
#1,418
of 3,149 outputs
Outputs of similar age
#39,704
of 348,359 outputs
Outputs of similar age from Cancer Cell
#21
of 50 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.