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Mendeley readers
| Title |
Engagement With the Auditory Processing System During Targeted Auditory Cognitive Training Mediates Changes in Cognitive Outcomes in Individuals With Schizophrenia
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|---|---|
| Published in |
Neuropsychology, November 2016
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| DOI | 10.1037/neu0000311 |
| Pubmed ID | |
| Authors |
Bruno Biagianti, Melissa Fisher, Torsten B. Neilands, Rachel Loewy, Sophia Vinogradov |
| Abstract |
Individuals with schizophrenia who engage in targeted cognitive training (TCT) of the auditory system show generalized cognitive improvements. The high degree of variability in cognitive gains maybe due to individual differences in the level of engagement of the underlying neural system target. 131 individuals with schizophrenia underwent 40 hours of TCT. We identified target engagement of auditory system processing efficiency by modeling subject-specific trajectories of auditory processing speed (APS) over time. Lowess analysis, mixed models repeated measures analysis, and latent growth curve modeling were used to examine whether APS trajectories were moderated by age and illness duration, and mediated improvements in cognitive outcome measures. We observed significant improvements in APS from baseline to 20 hours of training (initial change), followed by a flat APS trajectory (plateau) at subsequent time-points. Participants showed interindividual variability in the steepness of the initial APS change and in the APS plateau achieved and sustained between 20 and 40 hours. We found that participants who achieved the fastest APS plateau, showed the greatest transfer effects to untrained cognitive domains. There is a significant association between an individual's ability to generate and sustain auditory processing efficiency and their degree of cognitive improvement after TCT, independent of baseline neurocognition. APS plateau may therefore represent a behavioral measure of target engagement mediating treatment response. Future studies should examine the optimal plateau of auditory processing efficiency required to induce significant cognitive improvements, in the context of interindividual differences in neural plasticity and sensory system efficiency that characterize schizophrenia. (PsycINFO Database Record |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 85 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 19% |
| Researcher | 12 | 14% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Doctoral Student | 7 | 8% |
| Student > Bachelor | 6 | 7% |
| Other | 14 | 16% |
| Unknown | 20 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 32 | 37% |
| Neuroscience | 8 | 9% |
| Medicine and Dentistry | 6 | 7% |
| Agricultural and Biological Sciences | 4 | 5% |
| Nursing and Health Professions | 3 | 3% |
| Other | 6 | 7% |
| Unknown | 27 | 31% |