| Title |
Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus
|
|---|---|
| Published in |
Osteoporosis International, September 2016
|
| DOI | 10.1007/s00198-016-3716-2 |
| Pubmed ID | |
| Authors |
A. A. Khan, D. A. Hanley, R. Rizzoli, J. Bollerslev, J.E.M Young, L. Rejnmark, R. Thakker, P. D’Amour, T. Paul, S. Van Uum, M. Zakaria Shrayyef, D. Goltzman, S. Kaiser, N. E. Cusano, R. Bouillon, L. Mosekilde, A. W. Kung, S. D. Rao, S. K. Bhadada, B. L. Clarke, J. Liu, Q. Duh, E. Michael Lewiecki, F. Bandeira, R. Eastell, C. Marcocci, S. J. Silverberg, R. Udelsman, K. Shawn Davison, J. T. Potts, M. L. Brandi, J. P. Bilezikian |
| Abstract |
The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH). It is most commonly seen after the age of 50 years, with women predominating by three to fourfold. In countries with routine multichannel screening, PHPT is identified earlier and may be asymptomatic. Where biochemical testing is not routine, PHPT is more likely to present with skeletal complications, or nephrolithiasis. Parathyroidectomy (PTx) is indicated for those with symptomatic disease. For asymptomatic patients, recent guidelines have recommended criteria for surgery, however PTx can also be considered in those who do not meet criteria, and prefer surgery. Non-surgical therapies are available when surgery is not appropriate. This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 30% |
| Mexico | 1 | 10% |
| Switzerland | 1 | 10% |
| Netherlands | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 90% |
| Scientists | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 415 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Syrian Arab Republic | 1 | <1% |
| Unknown | 414 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 51 | 12% |
| Student > Master | 50 | 12% |
| Student > Ph. D. Student | 40 | 10% |
| Student > Postgraduate | 35 | 8% |
| Student > Bachelor | 35 | 8% |
| Other | 84 | 20% |
| Unknown | 120 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 203 | 49% |
| Nursing and Health Professions | 14 | 3% |
| Biochemistry, Genetics and Molecular Biology | 8 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 2% |
| Business, Management and Accounting | 5 | 1% |
| Other | 28 | 7% |
| Unknown | 149 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2023.
All research outputs
#3,046,964
of 26,017,215 outputs
Outputs from Osteoporosis International
#512
of 3,933 outputs
Outputs of similar age
#49,130
of 345,389 outputs
Outputs of similar age from Osteoporosis International
#10
of 65 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,933 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 86% of its peers.
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We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.