Title |
Genetic Susceptibility in IBD
|
---|---|
Published in |
Inflammatory Bowel Diseases, February 2013
|
DOI | 10.1097/mib.0b013e3182810041 |
Pubmed ID | |
Authors |
James D. Doecke, Lisa A. Simms, Zhen Zhen Zhao, Ning Huang, Katherine Hanigan, Krupa Krishnaprasad, Rebecca L. Roberts, Jane M. Andrews, Gillian Mahy, Peter Bampton, Peter Lewindon, Timothy Florin, Ian C. Lawrance, Richard B. Gearry, Grant W. Montgomery, Graham L. Radford-Smith |
Abstract |
The etiology of ulcerative colitis (UC) and Crohn's disease (CD) involves both genetic and environmental components. Multiple UC and CD susceptibility genes have been identified through genome-wide association studies and subsequent meta-analyses. These studies have also highlighted the presence of genes common to both diseases, and shared with several other autoimmune disorders. The aim of this study was to identify single nucleotide polymorphisms (SNPs) recently identified by the International IBD Genetics Consortium (IIBDGC) demonstrating that highly significant associations with CD could also confer genetic susceptibility to UC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 22% |
United States | 2 | 22% |
Spain | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hong Kong | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 31% |
Researcher | 8 | 23% |
Student > Bachelor | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Student > Master | 2 | 6% |
Other | 4 | 11% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 34% |
Agricultural and Biological Sciences | 10 | 29% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Computer Science | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 9% |
Unknown | 5 | 14% |