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Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet

Overview of attention for article published in Physiology & Behavior, January 2011
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

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1 blog
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2 Facebook pages

Citations

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16 Dimensions

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68 Mendeley
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Title
Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet
Published in
Physiology & Behavior, January 2011
DOI 10.1016/j.physbeh.2011.01.013
Pubmed ID
Authors

Floyd H. Chilton, Tammy C. Lee, Stephanie L Willard, Priscilla Ivester, Susan Sergeant, Thomas C. Register, Carol A. Shively

Abstract

Research over the past 15 years has suggested a high comorbidity of depression and coronary heart disease (CHD). However the mechanisms responsible for this relationship are poorly understood. This study was designed to examine the relationships between depressive behaviors and concentrations of circulating lipids and lipid signaling molecules that may be common to both CHD and depression in a cohort of cynomolgus monkeys (Macaca fascicularis) consuming a 'Western' diet, enriched with saturated fat and cholesterol. Socially-housed adult female cynomolgus monkeys (n=36) were fed the Western diet for 27 months and depressive behavior was recorded weekly. Body weight, body mass index and circulating cholesterol profiles were measured in all animals, and fatty acids (FA) and FA-based signaling molecules were measured in the 6 least and 6 most depressed monkeys. Monkeys consuming the Western diet exhibited a broad range of percent time spent in depressive behavior. The percent time spent depressed was positively correlated with total plasma and LDL cholesterol and negatively correlated with HDL cholesterol. Despite being leaner, depressed monkeys had higher concentrations of monounsaturated fats (C16:1 and C17:1), a higher ω6/ω3 polyunsaturated fatty acid (PUFA) ratio and higher concentrations of omega-6 (ω6) PUFAs, particularly C18:2ω6 and C20:3ω6. FA ratios suggest that stearoyl CoA desaturase 1 activity was increased in depressed monkeys. Depressed female cynomolgus monkeys had elevated concentrations of serum lipids and lipid signaling molecules that are typically associated with obesity, insulin resistance and cardiovascular disease, which may account in part for the comorbidity of depression and CHD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Unknown 66 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 21%
Researcher 11 16%
Student > Ph. D. Student 9 13%
Student > Master 6 9%
Professor 5 7%
Other 9 13%
Unknown 14 21%
Readers by discipline Count As %
Medicine and Dentistry 11 16%
Agricultural and Biological Sciences 8 12%
Nursing and Health Professions 7 10%
Psychology 5 7%
Biochemistry, Genetics and Molecular Biology 5 7%
Other 11 16%
Unknown 21 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2019.
All research outputs
#2,863,727
of 25,373,627 outputs
Outputs from Physiology & Behavior
#873
of 5,537 outputs
Outputs of similar age
#16,512
of 193,528 outputs
Outputs of similar age from Physiology & Behavior
#7
of 26 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,528 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.