| Title |
Streptavidin Modified ZnO Film Bulk Acoustic Resonator for Detection of Tumor Marker Mucin 1
|
|---|---|
| Published in |
Discover Nano, September 2016
|
| DOI | 10.1186/s11671-016-1612-5 |
| Pubmed ID | |
| Authors |
Dan Zheng, Peng Guo, Juan Xiong, Shengfu Wang |
| Abstract |
A ZnO-based film bulk acoustic resonator has been fabricated using a magnetron sputtering technology, which was employed as a biosensor for detection of mucin 1. The resonant frequency of the thin-film bulk acoustic resonator was located near at 1503.3 MHz. The average electromechanical coupling factor [Formula: see text] and quality factor Q were 2.39 % and 224, respectively. Using the specific binding system of avidin-biotin, the streptavidin was self-assembled on the top gold electrode as the sensitive layer to indirectly test the MUC1 molecules. The resonant frequency of the biosensor decreases in response to the mass loading in range of 20-500 nM. The sensor modified with the streptavidin exhibits a high sensitivity of 4642.6 Hz/nM and a good selectivity. |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 5% |
| Unknown | 21 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 23% |
| Student > Ph. D. Student | 4 | 18% |
| Student > Master | 4 | 18% |
| Student > Bachelor | 2 | 9% |
| Professor > Associate Professor | 2 | 9% |
| Other | 2 | 9% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 8 | 36% |
| Materials Science | 3 | 14% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Computer Science | 1 | 5% |
| Chemical Engineering | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 5 | 23% |