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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The integrated stress response
|
|---|---|
| Published in |
EMBO Reports, September 2016
|
| DOI | 10.15252/embr.201642195 |
| Pubmed ID | |
| Authors |
Karolina Pakos‐Zebrucka, Izabela Koryga, Katarzyna Mnich, Mila Ljujic, Afshin Samali, Adrienne M Gorman |
| Abstract |
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by one of four members of the eIF2α kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 2 | 22% |
| Germany | 1 | 11% |
| Spain | 1 | 11% |
| Canada | 1 | 11% |
| United Kingdom | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 56% |
| Members of the public | 4 | 44% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,686 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 1682 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 379 | 22% |
| Researcher | 210 | 12% |
| Student > Bachelor | 206 | 12% |
| Student > Master | 171 | 10% |
| Student > Doctoral Student | 75 | 4% |
| Other | 187 | 11% |
| Unknown | 458 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 574 | 34% |
| Agricultural and Biological Sciences | 252 | 15% |
| Neuroscience | 84 | 5% |
| Medicine and Dentistry | 83 | 5% |
| Immunology and Microbiology | 54 | 3% |
| Other | 148 | 9% |
| Unknown | 491 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#554,960
of 25,837,817 outputs
Outputs from EMBO Reports
#128
of 4,117 outputs
Outputs of similar age
#10,469
of 333,965 outputs
Outputs of similar age from EMBO Reports
#4
of 40 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,117 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,965 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.