Title |
Update on the Performance and Application of Basophil Activation Tests
|
---|---|
Published in |
Current Allergy and Asthma Reports, November 2012
|
DOI | 10.1007/s11882-012-0324-x |
Pubmed ID | |
Authors |
Emily C. McGowan, Sarbjit Saini |
Abstract |
The basophil activation test (BAT) is a flow-cytometry-based functional assay that assesses the degree of cell activation after exposure to a stimuli. Though no standardized technique currently exists, recent advances have improved the performance of this assay, including identification of new basophil-specific markers and comparisons of the expression of CD63 to CD203c during activation. The basophil activation test has also been validated for many IgE-mediated disease conditions, which have been extensively reviewed elsewhere. This review focuses on the most recent applications of this test to the diagnosis of allergy to drugs, foods, venoms, and pollens, and the evolving role of the BAT in monitoring immunotherapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | <1% |
United States | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 128 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 19% |
Researcher | 19 | 15% |
Student > Bachelor | 16 | 12% |
Other | 10 | 8% |
Student > Master | 10 | 8% |
Other | 15 | 11% |
Unknown | 36 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 20% |
Agricultural and Biological Sciences | 19 | 15% |
Immunology and Microbiology | 17 | 13% |
Biochemistry, Genetics and Molecular Biology | 13 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
Other | 7 | 5% |
Unknown | 43 | 33% |