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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A DNA Circuit for IsomiR Detection
|
|---|---|
| Published in |
ChemBioChem, October 2016
|
| DOI | 10.1002/cbic.201600452 |
| Pubmed ID | |
| Authors |
Ashley R. Connolly, Rena Hirani, Amanda V. Ellis, Matt Trau |
| Abstract |
A synthetic DNA oligonucleotide has been programmed to function as a biological circuit to detect 5` IsomiRs. The circuit comprises of two integrated DNA switches. The first is 'activated' when a DNA probe is enzymatically modified by a reverse transcriptase that incorporates nucleotides complementary to the 5` region of a micro RNA (miRNA). Addition of the correct number and sequence of nucleotides enables the probe to assemble into an asymmetric DNA hairpin. The reconfigured hairpin probe then primes an internal polymerisation reaction resulting in the synthesis of a symmetrical DNA hairpin. This activates the second switch which then initiates the amplification of reverse transcribed miRNA through a continuous cycle of DNA nicking and polymerisation. The DNA circuit enables sensitive and rapid detection of femtomoles of a miRNA transcript under isothermal conditions. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 20% |
| Professor | 1 | 10% |
| Student > Doctoral Student | 1 | 10% |
| Student > Master | 1 | 10% |
| Unknown | 5 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 20% |
| Agricultural and Biological Sciences | 1 | 10% |
| Chemistry | 1 | 10% |
| Unknown | 6 | 60% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2017.
All research outputs
#13,786,643
of 24,577,646 outputs
Outputs from ChemBioChem
#2,855
of 5,916 outputs
Outputs of similar age
#161,448
of 325,596 outputs
Outputs of similar age from ChemBioChem
#16
of 87 outputs
Altmetric has tracked 24,577,646 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,916 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,596 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.