| Title |
Age at menarche and age at natural menopause in East Asian women: a genome-wide association study
|
|---|---|
| Published in |
GeroScience, September 2016
|
| DOI | 10.1007/s11357-016-9939-5 |
| Pubmed ID | |
| Authors |
Jiajun Shi, Ben Zhang, Ji-Yeob Choi, Yu-Tang Gao, Huaixing Li, Wei Lu, Jirong Long, Daehee Kang, Yong-Bing Xiang, Wanqing Wen, Sue K. Park, Xingwang Ye, Dong-Young Noh, Ying Zheng, Yiqin Wang, Seokang Chung, Xu Lin, Qiuyin Cai, Xiao-Ou Shu |
| Abstract |
Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high heritability. Abnormal timing of menarche or menopause is associated with a reduced span of fertility and risk for several age-related diseases including breast, endometrial and ovarian cancer, cardiovascular disease, and osteoporosis. To identify novel genetic loci for AM or ANM in East Asian women and to replicate previously identified loci primarily in women of European ancestry by genome-wide association studies (GWASs), we conducted a two-stage GWAS. Stage I aimed to discover promising novel AM and ANM loci using GWAS data of 8073 women from Shanghai, China. The Stage II replication study used the data from another Chinese GWAS (n = 1230 for AM and n = 1458 for ANM), a Korean GWAS (n = 4215 for AM and n = 1739 for ANM), and de novo genotyping of 2877 additional Chinese women. Previous GWAS-identified loci for AM and ANM were also evaluated. We identified two suggestive menarcheal age loci tagged by rs79195475 at 10q21.3 (beta = -0.118 years, P = 3.4 × 10(-6)) and rs1023935 at 4p15.1 (beta = -0.145 years, P = 4.9 × 10(-6)) and one menopausal age locus tagged by rs3818134 at 22q12.2 (beta = -0.276 years, P = 8.8 × 10(-6)). These suggestive loci warrant a further validation in independent populations. Although limited by low statistical power, we replicated 19 of the 98 menarche loci and 5 of the 20 menopause loci previously identified in women of European ancestry in East Asian women, suggesting a shared genetic architecture for these two traits across populations. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 40% |
| Greece | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 71 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 20% |
| Researcher | 7 | 10% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Doctoral Student | 4 | 6% |
| Other | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 26 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 32% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Nursing and Health Professions | 5 | 7% |
| Agricultural and Biological Sciences | 5 | 7% |
| Psychology | 3 | 4% |
| Other | 4 | 6% |
| Unknown | 25 | 35% |
Attention Score in Context
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#14,914,476
of 25,374,647 outputs
Outputs from GeroScience
#1,016
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#177,003
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Outputs of similar age from GeroScience
#8
of 15 outputs
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