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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Delayed liver regeneration in C3H/HeJ mice: possible involvement of haemodynamic and structural changes in the hepatic microcirculation
|
|---|---|
| Published in |
Experimental Physiology, December 2016
|
| DOI | 10.1113/ep085727 |
| Pubmed ID | |
| Authors |
Muhamad Marlini, Ayako Mabuchi, Beth L. Mallard, Ngatiman Hairulhisyam, Sachiko Akashi‐Takamura, Jacquie L. Harper, Antony M. Wheatley |
| Abstract |
Liver regeneration is delayed in mice with a defective TLR4 (C3H/HeJ) but is normal in TLR4 knockouts (TLR4(-/-) ). Here, we investigated the possible involvement of structural and hemodynamic changes in vivo in the underlying mechanism. In LPS-sensitive (C3H/HeN, C57BL/6) and LPS-insensitive (C3H/HeJ, TLR4(-/-) ) mice, a 70% partial hepatectomy (PH) was performed under inhalational anesthesia. At days 3 and 7 after PH, the hepatic microcirculation was interrogated using intravital microscopy. Delayed liver regeneration was confirmed in C3H/HeJ, but not in C3H/HeN, C57BL/6 (WT) or TLR4(-/-) mice by liver weight-to-body-weight ratio, percentage of PCNA-positive cells and mitotic index data. At day 3 after PH, sinusoidal RBC velocity increased by 100% in C3H/HeN but only by 40% in C3H/HeJ mice. Estimated sinusoidal blood flow was significantly higher at day 7 after PH in C3H/HeN than in C3H/HeJ mice. The hepatic cord width was significantly larger in C3H/HeN than in C3H/HeJ mice at day 3 and it was significantly larger in TLR4(-/-) than in C57BL/6 WT mice at day 7 after PH. Hepatocyte nucleus density and functional sinusoidal density was significantly reduced at days 3 and 7 after PH in all mouse strains compared to their zero-time controls. Functional sinusoidal density was significantly lower in C3H/HeJ compared to C3H/HeN mice at day 7 after PH. The present study indicates that altered sinusoidal blood flow and velocity in C3H/HeJ mice may contribute to the observed delay in regenerative response in these mice. In addition, restoration of normal liver architecture may be delayed in TLR4(-/-) mice. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 21% |
| Student > Ph. D. Student | 2 | 14% |
| Student > Postgraduate | 2 | 14% |
| Professor | 1 | 7% |
| Student > Master | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 4 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 29% |
| Biochemistry, Genetics and Molecular Biology | 2 | 14% |
| Agricultural and Biological Sciences | 2 | 14% |
| Materials Science | 1 | 7% |
| Unknown | 5 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2016.
All research outputs
#3,152,330
of 25,457,858 outputs
Outputs from Experimental Physiology
#393
of 2,530 outputs
Outputs of similar age
#57,680
of 416,977 outputs
Outputs of similar age from Experimental Physiology
#10
of 43 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,530 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,977 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.