Chapter title |
Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response
|
---|---|
Book title |
Coronaviruses
|
Published in |
Advances in Virus Research, January 2016
|
DOI | 10.1016/bs.aivir.2016.08.006 |
Pubmed ID | |
Book ISBNs |
978-0-12-804736-1
|
Authors |
E. Kindler, V. Thiel, F. Weber |
Abstract |
Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans. The causative agents, SARS-CoV and MERS-CoV, are of zoonotic origin but may be transmitted to humans, causing severe and often fatal respiratory disease in their new host. The two coronaviruses are thought to encode an unusually large number of factors that allow them to thrive and replicate in the presence of efficient host defense mechanisms, especially the antiviral interferon system. Here, we review the recent progress in our understanding of the strategies that highly pathogenic coronaviruses employ to escape, dampen, or block the antiviral interferon response in human cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 40% |
United States | 2 | 40% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 380 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 65 | 17% |
Student > Bachelor | 59 | 16% |
Researcher | 50 | 13% |
Student > Master | 32 | 8% |
Other | 21 | 6% |
Other | 66 | 17% |
Unknown | 87 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 76 | 20% |
Immunology and Microbiology | 63 | 17% |
Medicine and Dentistry | 44 | 12% |
Agricultural and Biological Sciences | 33 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 4% |
Other | 46 | 12% |
Unknown | 101 | 27% |