| Title |
Evaluation of the cytotoxic effect and antibacterial, antifungal, and antiviral activities of Hypericum triquetrifolium Turra essential oils from Tunisia
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, January 2013
|
| DOI | 10.1186/1472-6882-13-24 |
| Pubmed ID | |
| Authors |
Zyed Rouis, Nabil Abid, Sadok Koudja, Thabet Yangui, Ameur Elaissi, Pier Luigi Cioni, Guido Flamini, Mahjoub Aouni |
| Abstract |
ABSTRACT: BACKGROUND: A number of bio-active secondary metabolites have been identified and reported for several Hypericum species. Many studies have reported the potential use of the plant extracts against several pathogens. However, Hypericum triquetrifolium is one of the least studied species for its antimicrobial activity. The aim of the present study was to evaluate the cytotoxic effect of the essential oils of Hypericum triquetrifolium as well as their antimicrobial potential against coxsakievirus B3 and a range of bacterial and fungal strains. METHODS: The essential oils of Hypericum triquetrifolium harvested from five different Tunisian localities (Fondouk DJedid, Bou Arada, Bahra, Fernana and Dhrea Ben Jouder) were evaluated for their antimicrobial activities by micro-broth dilution methods against bacterial and fungal strains. In addition, the cytotoxic effect and the antiviral activity of these oils were carried out using Vero cell lines and coxsakievirus B3. RESULTS: The results showed a good antibacterial activities against a wide range of bacterial strains, MIC values ranging between 0.39-12.50 mg/ml and MBC values between 1.56-25.0 mg/ml. In addition, the essential oils showed promising antifungal activity with MIC values ranging between 0.39 mug/mL and 12.50 mug/mL; MFC values ranged between 3.12 mug/mL and 25.00 mug/mL; a significant anticandidal activity was noted (MIC values comprised between 0.39 mug/mL and 12.50 mug/mL). Although their low cytotoxic effect (CC50 ranged between 0.58 mg/mL and 12.00 mg/mL), the essential oils did not show antiviral activity against coxsakievirus B3. CONCLUSION: The essential oils obtained from Hypericum triquetrifolium can be used as antimicrobial agents and could be safe at non cytotoxic doses. As shown for the tested essential oils, comparative analysis need to be undertaken to better characterize also the antimicrobial activities of Hypericum triquetrifolium extracts with different solvents as well as their purified fractions and their pure secondary metabolites. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Cameroon | 1 | 1% |
| Italy | 1 | 1% |
| Morocco | 1 | 1% |
| Unknown | 68 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 13% |
| Researcher | 8 | 11% |
| Student > Postgraduate | 8 | 11% |
| Student > Doctoral Student | 6 | 8% |
| Student > Ph. D. Student | 6 | 8% |
| Other | 17 | 24% |
| Unknown | 17 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 31% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Medicine and Dentistry | 4 | 6% |
| Immunology and Microbiology | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 17 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2016.
All research outputs
#2,588,813
of 22,694,633 outputs
Outputs from BMC Complementary Medicine and Therapies
#456
of 3,619 outputs
Outputs of similar age
#28,057
of 282,817 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#10
of 66 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,619 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.