| Title |
Gestational changes in left ventricular myocardial contractile function: new insights from two-dimensional speckle tracking echocardiography
|
|---|---|
| Published in |
The International Journal of Cardiovascular Imaging, September 2016
|
| DOI | 10.1007/s10554-016-0977-y |
| Pubmed ID | |
| Authors |
Shantanu P. Sengupta, Manish Bansal, Leonard Hofstra, Partho P. Sengupta, Jagat Narula |
| Abstract |
The goal of this study was to evaluate the impact of pregnancy and labor on left ventricular (LV) myocardial mechanics using speckle tracking echocardiography (STE). Pregnancy is characterized by profound hormonal and hemodynamic alterations that directly or indirectly influence cardiac structure and function. However, the impact of these changes on left ventricular (LV) myocardial contractile function has not been fully elucidated. In this prospective, longitudinal study, 35 pregnant women underwent serial clinical and echocardiographic evaluation during each trimester and at labor. Two dimensional STE was performed to measure global LV longitudinal, circumferential and radial strain (GLS, GCS and GRS, respectively). Similar data obtained from 20 nulliparous, age-matched women were used as control. All strain values during pregnancy were adjusted for age and hemodynamic parameters. There was a progressive increase in heart rate, systolic and diastolic blood pressure, cardiac output and LV stroke-work during pregnancy. LV end-diastolic and end-systolic volumes also increased progressively but LV ejection fraction remained unaltered, except for slight reduction during the second trimester. Compared to the controls, GLS and GCS were reduced in the first trimester itself (GLS -22.39 ± 5.43 % vs. -18.66 ± 0.64 %, P 0.0002; GCS -20.84 ± 3.20 vs. -17.88 ± 0.09, P < 0.001) and remained so throughout the pregnancy and labor. In contrast, GRS showed an increase during pregnancy which peaked during the second trimester (24.18 ± 0.39 % vs. 18.06 ± 8.14 % in controls, P < 0.001). Alterations in loading conditions during pregnancy are associated with counterbalancing changes in the myocardial mechanics. LV longitudinal and circumferential strain are reduced whereas radial strain is increased. These counterbalancing changes serve to maintain overall LV ejection performance within a normal range and enable the maternal heart to meet the hemodynamic demands of pregnancy and labor. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 12% |
| Student > Postgraduate | 5 | 12% |
| Student > Master | 5 | 12% |
| Other | 4 | 10% |
| Student > Doctoral Student | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 14 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 54% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Psychology | 1 | 2% |
| Computer Science | 1 | 2% |
| Unknown | 16 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2016.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from The International Journal of Cardiovascular Imaging
#1,116
of 2,012 outputs
Outputs of similar age
#242,342
of 330,507 outputs
Outputs of similar age from The International Journal of Cardiovascular Imaging
#16
of 35 outputs
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