| Title |
Nutraceuticals for Treatment of High Blood Pressure Values in Patients with Metabolic Syndrome
|
|---|---|
| Published in |
High Blood Pressure & Cardiovascular Prevention, January 2013
|
| DOI | 10.2165/11530420-000000000-00000 |
| Pubmed ID | |
| Authors |
Francesco Rozza, Giovanni de Simone, Raffaele Izzo, Nicola De Luca, Bruno Trimarco |
| Abstract |
Aim: To assess whether the association of a dietary supplement with a correct diet can decrease the incidence of metabolic syndrome. In particular, we studied the effect of a combination of Ortosiphon staminensis, which in rats exerts a diuretic effect, with policosanol, red yeast rice extract, berberine, folic acid and coenzyme Q(10) on the determinants of metabolic syndrome diagnosis. Methods: The analysed sample consisted of 21 males and 9 females, who were comparable in age, in order to obtain an adequate comparison between groups with similar demographic characteristics. Thirty patients with metabolic syndrome were divided into two study arms. Both groups received the usual diet recommended by the doctor according to their clinical conditions and placebo for 2 weeks before the beginning of the study, and then they were randomly assigned to two different drug regimens: placebo or the combination of nutraceuticals previously described, and were followed-up for 6 weeks. Results: At baseline, there were no significant differences between the study and control groups for age, sex distribution, waist measurement, body mass index, systolic and diastolic blood pressure, familiarity for cardiovascular events, smoking habit, fasting glucose and lipid profile.At the end of the follow-up, only in the study group was there a significant reduction in systolic and diastolic blood pressure (-19.6±9.7 vs -3.6±8.1 mmHg and -13.6±5.5 vs -2.3±5.3 mmHg; all p < 0.0001) associated with amarked decrease in low-density lipoprotein cholesterol and triglyceride plasma levels. Consequently, 10 of 15 patients in this group no longer satisfied the criteria for metabolic syndrome, while in the control group the ratio was of 2 of 15. Conclusions: The addition of Ortosiphon staminensis to the combination of policosanol, red yeast rice extract, berberine, folic acid and coenzyme Q(10) provides an antihypertensive effect, which allows an effective control of blood pressure in patients with metabolic syndrome. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 24% |
| Student > Bachelor | 7 | 19% |
| Student > Master | 6 | 16% |
| Professor | 3 | 8% |
| Professor > Associate Professor | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 6 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 22% |
| Agricultural and Biological Sciences | 4 | 11% |
| Nursing and Health Professions | 4 | 11% |
| Psychology | 2 | 5% |
| Unspecified | 1 | 3% |
| Other | 6 | 16% |
| Unknown | 12 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2013.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from High Blood Pressure & Cardiovascular Prevention
#191
of 275 outputs
Outputs of similar age
#228,796
of 289,019 outputs
Outputs of similar age from High Blood Pressure & Cardiovascular Prevention
#5
of 7 outputs
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So far Altmetric has tracked 275 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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