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Attention Score in Context
| Title |
Poly(ethylene glycol)-Based Hyperbranched Polymer from RAFT and Its Application as a Silver-Sulfadiazine-Loaded Antibacterial Hydrogel in Wound Care
|
|---|---|
| Published in |
ACS Applied Materials & Interfaces, September 2016
|
| DOI | 10.1021/acsami.6b11371 |
| Pubmed ID | |
| Authors |
Sean McMahon, Robert Kennedy, Patrick Duffy, Jeddah Marie Vasquez, J. Gerard Wall, Hongyun Tai, Wenxin Wang |
| Abstract |
A multifunctional branched co-polymer was synthesized by Reversible Addition- Fragmentation Chain Transfer polymerisation (RAFT) of poly (ethylene glycol) diacrylate (PEGDA Mn=575) and poly (ethylene glycol) methyl methacrylate (PEGMEMA Mn=500) at a feed molar ratio of 50:50. Proton nuclear magnetic resonance spectroscopy (1H NMR) confirmed a hyper branched molecular structure and a high degree of vinyl functionality. An in situ cross-linkable hydrogel system was generated via a "click" thiol-ene type Michael addition reaction of vinyl functional groups from this PEGDA/PEGMEMA copolymer system in combination with thiol-modified hyaluronic acid. Furthermore, encapsulation of antimicrobial silver sulfadiazine (SSD) into the copolymer system was conducted to create an advanced antimicrobial wound care dressing. This hydrogel demonstrated a sustained antibacterial activity against the bacterial strains Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli in comparison to the direct topical application of SSD. In addition, in vitro toxicology evaluations demonstrated that this hydrogel -with low concentrations of encapsulated SSD - supported the survival of embedded human adipose derived stem cells (hADSCs) and inhibited growth of the aforementioned pathogens. Here we demonstrate that this hydrogel encapsulated with a low concentration (1.0% w/v) of SSD can be utilized as a carrier system for stem cells with the ability to inhibit growth of pathogens and without adverse effects on hADSCs. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 19% |
| Student > Master | 10 | 15% |
| Researcher | 7 | 10% |
| Student > Doctoral Student | 6 | 9% |
| Student > Postgraduate | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 20 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Materials Science | 11 | 16% |
| Chemistry | 10 | 15% |
| Medicine and Dentistry | 5 | 7% |
| Agricultural and Biological Sciences | 4 | 6% |
| Chemical Engineering | 3 | 4% |
| Other | 12 | 18% |
| Unknown | 23 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2023.
All research outputs
#6,473,070
of 24,535,155 outputs
Outputs from ACS Applied Materials & Interfaces
#3,423
of 19,218 outputs
Outputs of similar age
#93,559
of 328,501 outputs
Outputs of similar age from ACS Applied Materials & Interfaces
#90
of 357 outputs
Altmetric has tracked 24,535,155 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 19,218 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,501 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 357 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.