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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis
|
|---|---|
| Published in |
Circulation, January 2013
|
| DOI | 10.1161/circulationaha.112.127472 |
| Pubmed ID | |
| Authors |
Andrey Anisimov, Denis Tvorogov, Annamari Alitalo, Veli-Matti Leppänen, Yuri An, Eun Chun Han, Fabrizio Orsenigo, Emília Ilona Gaál, Tanja Holopainen, Young Jun Koh, Tuomas Tammela, Petra Korpisalo, Salla Keskitalo, Michael Jeltsch, Seppo Ylä-Herttuala, Elisabetta Dejana, Gou Young Koh, Chulhee Choi, Pipsa Saharinen, Kari Alitalo |
| Abstract |
There is an unmet need for proangiogenic therapeutic molecules for the treatment of tissue ischemia in cardiovascular diseases. However, major inducers of angiogenesis such as vascular endothelial growth factor (VEGF/VEGF-A) have side effects that limit their therapeutic utility in vivo, especially at high concentrations. Angiopoietin-1 has been considered to be a blood vessel stabilization factor that can inhibit the intrinsic property of VEGF to promote vessel leakiness. In this study, we have designed and tested the angiogenic properties of chimeric molecules consisting of receptor-binding parts of VEGF and angiopoietin-1. We aimed at combining the activities of both factors into 1 molecule for easy delivery and expression in target tissues. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 2 | 3% |
| Poland | 1 | 1% |
| Unknown | 71 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 24% |
| Student > Ph. D. Student | 13 | 18% |
| Student > Doctoral Student | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Student > Master | 6 | 8% |
| Other | 14 | 19% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 28% |
| Biochemistry, Genetics and Molecular Biology | 14 | 19% |
| Agricultural and Biological Sciences | 13 | 18% |
| Nursing and Health Professions | 3 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 13 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2016.
All research outputs
#7,179,818
of 22,694,633 outputs
Outputs from Circulation
#10,892
of 19,617 outputs
Outputs of similar age
#81,499
of 282,817 outputs
Outputs of similar age from Circulation
#86
of 175 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 19,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,817 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 175 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.