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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Insulin gene therapy for type 1 diabetes mellitus.
|
|---|---|
| Published in |
Experimental and clinical transplantation official journal of the Middle East Society for Organ Transplantation, April 2015
|
| DOI | 10.6002/ect.mesot2014.l67 |
| Pubmed ID | |
| Authors |
Andrew M Handorf, Hans W Sollinger, Tausif Alam |
| Abstract |
Type 1 diabetes mellitus is an autoimmune disease resulting from the destruction of pancreatic β cells. Current treatments for patients with type 1 diabetes mellitus include daily insulin injections or whole pancreas transplant, each of which are associated with profound drawbacks. Insulin gene therapy, which has shown great efficacy in correcting hyperglycemia in animal models, holds great promise as an alternative strategy to treat type 1 diabetes mellitus in humans. Insulin gene therapy refers to the targeted expression of insulin in non-β cells, with hepatocytes emerging as the primary therapeutic target. In this review, we present an overview of the current state of insulin gene therapy to treat type 1 diabetes mellitus, including the need for an alternative therapy, important features dictating the success of the therapy, and current obstacles preventing the translation of this treatment option to a clinical setting. In so doing, we hope to shed light on insulin gene therapy as a viable option to treat type 1 diabetes mellitus. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Côte d'Ivoire | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 84 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 26% |
| Researcher | 9 | 11% |
| Student > Master | 9 | 11% |
| Student > Ph. D. Student | 7 | 8% |
| Student > Doctoral Student | 5 | 6% |
| Other | 7 | 8% |
| Unknown | 26 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 18% |
| Medicine and Dentistry | 14 | 16% |
| Agricultural and Biological Sciences | 12 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Computer Science | 3 | 4% |
| Other | 10 | 12% |
| Unknown | 28 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2020.
All research outputs
#14,280,554
of 25,382,440 outputs
Outputs from Experimental and clinical transplantation official journal of the Middle East Society for Organ Transplantation
#77
of 469 outputs
Outputs of similar age
#128,503
of 279,175 outputs
Outputs of similar age from Experimental and clinical transplantation official journal of the Middle East Society for Organ Transplantation
#4
of 34 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 469 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,175 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.