Title |
The Microbiome: a Revolution in Treatment for Rheumatic Diseases?
|
---|---|
Published in |
Current Rheumatology Reports, September 2016
|
DOI | 10.1007/s11926-016-0614-8 |
Pubmed ID | |
Authors |
James T. Rosenbaum, Mark J. Asquith |
Abstract |
The microbiome is the term that describes the microbial ecosystem that cohabits an organism such as humans. The microbiome has been implicated in a long list of immune-mediated diseases which include rheumatoid arthritis, ankylosing spondylitis, and even gout. The mechanisms to account for this effect are multiple. The clinical implications from observations on the microbiome and disease are broad. A growing number of microbiota constituents such as Prevotella copri, Porphyromonas gingivalis, and Collinsella have been correlated or causally related to rheumatic disease. The microbiome has a marked effect on the immune system. Our understanding of immune pathways modulated by the microbiota such as the induction of T helper 17 (Th17) cells and secretory immunoglobulin A (IgA) responses to segmented filamentous bacteria continues to expand. In addition to the gut microbiome, bacterial communities of other sites such as the mouth, lung, and skin have also been associated with the pathogenesis of rheumatic diseases. Strategies to alter the microbiome or to alter the immune activation from the microbiome might play a role in the future therapy for rheumatic diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 29% |
United Kingdom | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
India | 1 | <1% |
Unknown | 147 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 28 | 19% |
Student > Master | 22 | 15% |
Student > Bachelor | 15 | 10% |
Student > Ph. D. Student | 14 | 9% |
Student > Postgraduate | 12 | 8% |
Other | 39 | 26% |
Unknown | 21 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 27 | 18% |
Biochemistry, Genetics and Molecular Biology | 14 | 9% |
Immunology and Microbiology | 10 | 7% |
Nursing and Health Professions | 5 | 3% |
Other | 15 | 10% |
Unknown | 22 | 15% |