Title |
Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis
|
---|---|
Published in |
Current Diabetes Reports, September 2016
|
DOI | 10.1007/s11892-016-0782-y |
Pubmed ID | |
Authors |
Sherman S. Leung, Josephine M. Forbes, Danielle J. Borg |
Abstract |
The receptor for advanced glycation end products (RAGE) is a novel protein increasingly studied in the pathogenesis of type 1 diabetes (T1D). RAGE is expressed by several immune cell types, including T cells, antigen-presenting cells, endothelial cells, and the endocrine cells of the pancreatic islets. RAGE binds various ligands including advanced glycation end products (AGEs), high-mobility group box protein 1 (HMGB1), S100 proteins, β-amyloid, β-sheet fibrils, and lipopolysaccharide. AGEs are a particularly interesting ligand because their exogenous introduction into the body can be accelerated by the consumption of AGE-rich processed foods. This review will detail RAGE isoforms and its ligands and discuss how RAGE binding on the aforementioned cells could be linked to T1D pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 33% |
Japan | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 24% |
Student > Bachelor | 3 | 12% |
Researcher | 3 | 12% |
Student > Master | 3 | 12% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 16% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 20% |
Agricultural and Biological Sciences | 4 | 16% |
Medicine and Dentistry | 3 | 12% |
Chemistry | 2 | 8% |
Immunology and Microbiology | 2 | 8% |
Other | 3 | 12% |
Unknown | 6 | 24% |