| Title |
LRRK2 G2019S and R1441G mutations associated with Parkinson’s disease are common in the Basque Country, but relative prevalence is determined by ethnicity
|
|---|---|
| Published in |
neurogenetics, November 2008
|
| DOI | 10.1007/s10048-008-0162-0 |
| Pubmed ID | |
| Authors |
A. Gorostidi, J. Ruiz-Martínez, A. Lopez de Munain, A. Alzualde, J. F. Martí Massó |
| Abstract |
Mutations in LRRK2 gene are the most frequent cause of Parkinson's disease (PD) described, but their prevalence varies between populations. Patients, 418, with PD and 138 unrelated controls from the Basque Country were screened for LRRK2 G2019S and R1441G mutations. Of the patients, 3.82% were heterozygous carriers of G2019S and 13.15% of R1441G. G2019S frequency was higher in non-Basque population (6.0%), while R1441G was more common in Basque origin population (22.4%). Our conclusion is that both G2019S and R1441G mutations' frequency varies markedly between Basque and non-Basque origin population reinforcing the importance of ethnicity consideration when establishing mutation prevalence. |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Unknown | 60 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 31% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Master | 8 | 13% |
| Student > Bachelor | 6 | 10% |
| Student > Postgraduate | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 12 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 26% |
| Neuroscience | 13 | 21% |
| Agricultural and Biological Sciences | 8 | 13% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Psychology | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 12 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2013.
All research outputs
#4,577,288
of 22,694,633 outputs
Outputs from neurogenetics
#57
of 375 outputs
Outputs of similar age
#25,076
of 165,856 outputs
Outputs of similar age from neurogenetics
#3
of 4 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 375 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 84% of its peers.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.