| Title |
The Complex Role of Apolipoprotein E in Alzheimer’s Disease: an Overview and Update
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, September 2016
|
| DOI | 10.1007/s12031-016-0839-z |
| Pubmed ID | |
| Authors |
Laura Mahoney-Sanchez, Abdel Ali Belaidi, Ashley I. Bush, Scott Ayton |
| Abstract |
Apolipoprotein E (ApoE) plays a crucial role in the homeostatic control of lipids in both the periphery and the central nervous system (CNS). In humans, ApoE exists in three different isoforms: ε2, ε3 and ε4. ApoE ε3 is the most common isoform, while the ε4 isoform confers the greatest genetic risk for Alzheimer's disease (AD). However, the mechanisms underlying how ApoE contributes to the pathogenesis of AD are still debated. ApoE has been shown to impact amyloid β (Aβ) deposition and clearance in the brain. ApoE also has Aβ-independent pathways in AD, which has led to the discovery of new roles of ApoE ranging from mitochondria dysfunction to, most recently, iron metabolism. Here, we review the role of ApoE in health and in AD, with the view of identifying therapeutic approaches that could prevent the risk associated with the ε4 isoform. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 115 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 15% |
| Student > Ph. D. Student | 16 | 14% |
| Student > Bachelor | 15 | 13% |
| Researcher | 13 | 11% |
| Student > Doctoral Student | 9 | 8% |
| Other | 17 | 15% |
| Unknown | 29 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 28 | 24% |
| Medicine and Dentistry | 16 | 14% |
| Biochemistry, Genetics and Molecular Biology | 14 | 12% |
| Agricultural and Biological Sciences | 12 | 10% |
| Psychology | 5 | 4% |
| Other | 9 | 8% |
| Unknown | 33 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2017.
All research outputs
#2,983,081
of 25,373,627 outputs
Outputs from Journal of Molecular Neuroscience
#61
of 1,643 outputs
Outputs of similar age
#47,791
of 328,302 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#8
of 40 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,302 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.