| Title |
Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis
|
|---|---|
| Published in |
Journal of Neuro-Oncology, September 2016
|
| DOI | 10.1007/s11060-016-2278-7 |
| Pubmed ID | |
| Authors |
Akshitkumar M. Mistry, Andrew T. Hale, Lola B. Chambless, Kyle D. Weaver, Reid C. Thompson, Rebecca A. Ihrie |
| Abstract |
The ventricular-subventricular zone (V-SVZ), which lies in the walls of the lateral ventricles (LV), is the largest neurogenic niche within the adult brain. Whether radiographic contact with the LV influences survival in glioblastoma (GBM) patients remains unclear. We assimilated and analyzed published data comparing survival in GBM patients with (LV+GBM) and without (LV-GBM) radiographic LV contact. PubMed, EMBASE, and Cochrane electronic databases were searched. Fifteen studies with survival data on LV+GBM and LV-GBM patients were identified. Their Kaplan-Meier survival curves were digitized and pooled for generation of median overall (OS) and progression free (PFS) survivals and log-rank hazard ratios (HRs). The log-rank and reported multivariate HRs after accounting for the common predictors of GBM survival were analyzed separately by meta-analyses. The calculated median survivals (months) from pooled data were 12.95 and 16.58 (OS), and 4.54 and 6.25 (PFS) for LV+GBMs and LV-GBMs, respectively, with an overall log-rank HRs of 1.335 [1.204-1.513] (OS) and 1.387 [1.225-1.602] (PFS). Meta-analysis of log-rank HRs resulted in summary HRs of 1.58 [1.35-1.85] (OS, 10 studies) and 1.41 [1.22-1.64] (PFS, 5 studies). Meta-analysis of multivariate HRs resulted in summary HRs of 1.35 [1.14-1.58] (OS, 6 studies) and 1.64 [0.88-3.05] (PFS, 3 studies). Patients with GBM contacting the LV have lower survival. This effect may be independent of the common predictors of GBM survival, suggesting a clinical influence of V-SVZ contact on GBM biology. |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Unknown | 80 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 19% |
| Researcher | 8 | 10% |
| Student > Bachelor | 8 | 10% |
| Other | 7 | 9% |
| Professor > Associate Professor | 4 | 5% |
| Other | 16 | 20% |
| Unknown | 23 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 28% |
| Agricultural and Biological Sciences | 11 | 14% |
| Neuroscience | 6 | 7% |
| Unspecified | 3 | 4% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 5 | 6% |
| Unknown | 30 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2022.
All research outputs
#2,326,152
of 23,138,859 outputs
Outputs from Journal of Neuro-Oncology
#139
of 2,997 outputs
Outputs of similar age
#41,768
of 321,445 outputs
Outputs of similar age from Journal of Neuro-Oncology
#1
of 41 outputs
Altmetric has tracked 23,138,859 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,997 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.