| Title |
Significant correlation of TLR4 expression with the clinicopathological features of invasive ductal carcinoma of the breast
|
|---|---|
| Published in |
Tumor Biology, January 2013
|
| DOI | 10.1007/s13277-013-0645-y |
| Pubmed ID | |
| Authors |
Naureen Ehsan, Sheeba Murad, Tamour Ashiq, Muhammad Uzair Mansoor, Summer Gul, Samra Khalid, Muhammad Younas |
| Abstract |
Toll-like receptor 4 belongs to the family of pattern recognition receptors and is therefore an important part of innate immunity. Since the last decade, Toll-like receptors (TLRs) have gained much interest in cancer research due to their role in tumor progression. However, there is scarcity of data evaluating TLR4 expression in different cell populations of tumor in relation to clinicopathological parameters of invasive ductal carcinoma of the breast. Therefore, we investigated TLR4 expression in 50 primary invasive ductal carcinoma and 17 lymph node sections through immunohistochemistry. Significant association of TLR4 expression with local metastasis and absence of necrosis was observed. The incidence of lymph node metastasis was higher in patients with high TLR4 expression in the tumor cells. We also observed an interesting inverse relationship of TLR4 with necrosis. In endothelial and lymphocytic population constituting breast tumors, a significant association of TLR4 expression was seen with the tumor grade. Therefore, we conclude that TLR4 expression is of biological interest both as a prognostic marker as well as a possible therapeutic target. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 20% |
| Student > Ph. D. Student | 3 | 20% |
| Researcher | 2 | 13% |
| Other | 2 | 13% |
| Unspecified | 1 | 7% |
| Other | 2 | 13% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 27% |
| Biochemistry, Genetics and Molecular Biology | 4 | 27% |
| Agricultural and Biological Sciences | 3 | 20% |
| Chemistry | 1 | 7% |
| Unspecified | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 2 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2013.
All research outputs
#20,180,477
of 22,694,633 outputs
Outputs from Tumor Biology
#1,833
of 2,621 outputs
Outputs of similar age
#246,524
of 279,187 outputs
Outputs of similar age from Tumor Biology
#14
of 18 outputs
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