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Mendeley readers
Attention Score in Context
| Title |
Pilosebaceous targeting by isotretenoin-loaded invasomal gel for the treatment of eosinophilic pustular folliculitis: optimization, efficacy and cellular analysis
|
|---|---|
| Published in |
Drug Development & Industrial Pharmacy, November 2016
|
| DOI | 10.1080/03639045.2016.1239628 |
| Pubmed ID | |
| Authors |
Mohit Dwivedi, Vijay Sharma, Kamla Pathak |
| Abstract |
Eosinophilic pustular folliculitis is a secondary symptom associated with HIV infection appears as levels of CD4 lymphocyte cells and T4 lymphocyte cell. Isotretinoin, an analogue of vitamin A (retinoid) alters the DNA transcription mechanism and interferes in the process of DNA formation. It also inhibits the eosinophilic chemotactic factors present in sebaceous lipids and in the stratum corneum of patients suffering from this ailment. The present research was aimed to formulate isotretenoin loaded invasomal gel to deliver and target the drug to pilosebaceous follicular unit. Nine invasomal formulations (F1 - F9) were prepared applying 3(2) factorial designs and characterized. Formulation F9 was selected as optimized formulation due to optimum results and highest %CDP of 85.94 ± 1.86% in 8hr. TEM suggested uniformity in vesicles shape and size in F9 and developed as invasomal gel (IG). Clinical phase I, II and III studies will be required before using on human patients. CLSM validate that IG successfully reaches the pilosebaceous follicular unit and further studied on cell line (SZ-95) exhibited IC50 of ≤ 8 (25µM of isotretenoin). Cell cycle analysis confirmed IG arrested the cell growth up to 82% with insignificant difference to pure isotretenion. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 14% |
| Professor | 3 | 10% |
| Student > Master | 3 | 10% |
| Student > Postgraduate | 2 | 7% |
| Lecturer | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 13 | 45% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 21% |
| Medicine and Dentistry | 4 | 14% |
| Agricultural and Biological Sciences | 2 | 7% |
| Chemical Engineering | 1 | 3% |
| Business, Management and Accounting | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 13 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2016.
All research outputs
#16,048,009
of 25,374,917 outputs
Outputs from Drug Development & Industrial Pharmacy
#1,313
of 1,655 outputs
Outputs of similar age
#186,098
of 317,143 outputs
Outputs of similar age from Drug Development & Industrial Pharmacy
#5
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,655 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,143 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.