| Title |
Targeting Netrin-1 in glioblastoma stem-like cells inhibits growth, invasion, and angiogenesis
|
|---|---|
| Published in |
Tumor Biology, September 2016
|
| DOI | 10.1007/s13277-016-5314-5 |
| Pubmed ID | |
| Authors |
Tanwarat Sanvoranart, Aungkura Supokawej, Pakpoom Kheolamai, Yaowalak U-pratya, Niphon Poungvarin, Sith Sathornsumetee, Surapol Issaragrisil |
| Abstract |
Glioblastoma (GBM) is an aggressive malignant brain tumor that still lacks effective therapy. Glioblastoma stem cells (GBM-SCs) were identified to contribute to aggressive phenotypes and poor clinical outcomes for GBM. Netrin-1, an axon guidance molecule, has been found in several tumors in adults. However, the role of Netrin-1 in GBM-SCs remains largely unknown. In this study, CD133-positive U251 GBM cells were used as a putative GBM-SC population to identify the functions of Netrin-1. Using lentiviral transduction, Netrin-1 miR RNAi vectors were transduced into CD133-positive U251 cells. We demonstrated that cell proliferation and survival were decreased following targeted deletion of Netrin-1. Cell invasion was dramatically diminished in Netrin-1 knockdown GBM-SCs. Moreover, Netrin-1 knockdown GBM-SCs exhibited less proangiogenic activity. In conclusion, Netrin-1 may represent a therapeutic target in glioblastoma. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 21% |
| Researcher | 6 | 21% |
| Student > Ph. D. Student | 4 | 14% |
| Student > Doctoral Student | 2 | 7% |
| Professor | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 6 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 21% |
| Biochemistry, Genetics and Molecular Biology | 6 | 21% |
| Medicine and Dentistry | 4 | 14% |
| Agricultural and Biological Sciences | 1 | 3% |
| Computer Science | 1 | 3% |
| Other | 4 | 14% |
| Unknown | 7 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2017.
All research outputs
#14,861,841
of 22,889,074 outputs
Outputs from Tumor Biology
#969
of 2,623 outputs
Outputs of similar age
#192,858
of 320,232 outputs
Outputs of similar age from Tumor Biology
#26
of 82 outputs
Altmetric has tracked 22,889,074 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,623 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
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We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.