| Title |
Intestinal Dysbiosis and Yeast Isolation in Stool of Subjects with Autism Spectrum Disorders
|
|---|---|
| Published in |
Mycopathologia, September 2016
|
| DOI | 10.1007/s11046-016-0068-6 |
| Pubmed ID | |
| Authors |
Maria Rosaria Iovene, Francesca Bombace, Roberta Maresca, Anna Sapone, Patrizia Iardino, Annarita Picardi, Rosa Marotta, Chiara Schiraldi, Dario Siniscalco, Nicola Serra, Laura de Magistris, Carmela Bravaccio |
| Abstract |
High frequency of gastrointestinal yeast presence in ASD subjects was shown through a simple cultural approach (Candida spp. in 57.5 % of ASDs and no controls); the identification of aggressive form (pseudo-hyphae presenting) of Candida spp. at light microscope means that adhesion to intestinal mucosa is facilitated. Dysbiosis appears sustained by lowered Lactobacillus spp. and decreased number of Clostridium spp. Absence of C. difficilis and its toxins in both ASDs and controls is also shown. Low-mild gut inflammation and augmented intestinal permeability were demonstrated together with the presence of GI symptoms. Significant linear correlation was found between disease severity (CARs score) and calprotectin and Clostridium spp. presence. Also GI symptoms, such as constipation and alternating bowel, did correlate (multivariate analyses) with the increased permeability to lactulose. The present data provide rationale basis to a possible specific therapeutic intervention in restoring gut homeostasis in ASDs. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 43% |
| Australia | 2 | 7% |
| Ireland | 1 | 4% |
| United Kingdom | 1 | 4% |
| Belgium | 1 | 4% |
| France | 1 | 4% |
| Unknown | 10 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 82% |
| Scientists | 3 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 227 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 227 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 38 | 17% |
| Student > Bachelor | 37 | 16% |
| Researcher | 24 | 11% |
| Student > Ph. D. Student | 21 | 9% |
| Student > Doctoral Student | 12 | 5% |
| Other | 34 | 15% |
| Unknown | 61 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 44 | 19% |
| Biochemistry, Genetics and Molecular Biology | 28 | 12% |
| Nursing and Health Professions | 19 | 8% |
| Neuroscience | 16 | 7% |
| Agricultural and Biological Sciences | 12 | 5% |
| Other | 34 | 15% |
| Unknown | 74 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2019.
All research outputs
#1,262,930
of 25,654,806 outputs
Outputs from Mycopathologia
#13
of 1,178 outputs
Outputs of similar age
#22,385
of 329,192 outputs
Outputs of similar age from Mycopathologia
#1
of 20 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,178 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.