| Title |
Outcomes After Mastectomy and Lumpectomy in Elderly Patients with Early-Stage Breast Cancer
|
|---|---|
| Published in |
Annals of Surgical Oncology, September 2016
|
| DOI | 10.1245/s10434-016-5582-8 |
| Pubmed ID | |
| Authors |
Harveshp D. Mogal, Clancy Clark, Rebecca Dodson, Nora F. Fino, Marissa Howard-McNatt |
| Abstract |
Survival in elderly patients undergoing mastectomy or lumpectomy has not been specifically analyzed. Patients older than 70 years of age with clinical stage I invasive breast cancer, undergoing mastectomy or lumpectomy with or without radiation, and surveyed within 3 years of their diagnosis, were identified from the Surveillance, Epidemiology, and End Results and medicare health outcomes survey-linked dataset. The primary endpoint was breast cancer-specific survival (CSS). Of 1784 patients, 596 (33.4 %) underwent mastectomy, 918 (51.4 %) underwent lumpectomy with radiation, and 270 (15.1 %) underwent lumpectomy alone. Significant differences were noted in age, tumor size, American Joint Committee on Cancer (AJCC) stage, lymph node status (all p < 0.0001) and number of positive lymph nodes between the three groups (p = 0.003). On univariate analysis, CSS for patients undergoing lumpectomy with radiation [hazard ratio (HR) 0.61, 95 % confidence interval (CI) 0.43-0.85; p = 0.004] was superior to mastectomy. Older age (HR 1.3, 95 % CI 1.09-1.45; p = 0.002), two or more comorbidities (HR 1.57, 95 % CI 1.08-2.26; p = 0.02), inability to perform more than two activities of daily living (HR 1.61, 95 % CI 1.06-2.44; p = 0.03), larger tumor size (HR 2.36, 95 % CI 1.85-3.02; p < 0.0001), and positive lymph nodes (HR 2.83, 95 % CI 1.98-4.04; p < 0.0001) were associated with worse CSS. On multivariate analysis, larger tumor size (HR 1.89, 95 % CI 1.37-2.57; p < 0.0001) and positive lymph node status (HR 1.99, 95 % CI 1.36-2.9; p = 0.0004) independently predicted worse survival. Elderly patients with early-stage invasive breast cancer undergoing breast conservation have better CSS than those undergoing mastectomy. After adjusting for comorbidities and functional status, survival is dependent on tumor-specific variables. Determination of lymph node status remains important in staging elderly breast cancer patients. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 41% |
| Spain | 7 | 16% |
| United Kingdom | 3 | 7% |
| Mexico | 1 | 2% |
| France | 1 | 2% |
| Philippines | 1 | 2% |
| Unknown | 13 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 66% |
| Practitioners (doctors, other healthcare professionals) | 9 | 20% |
| Scientists | 6 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 20% |
| Student > Bachelor | 5 | 14% |
| Researcher | 5 | 14% |
| Student > Ph. D. Student | 4 | 11% |
| Other | 2 | 6% |
| Other | 5 | 14% |
| Unknown | 7 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 43% |
| Social Sciences | 3 | 9% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Nursing and Health Professions | 2 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 9 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2017.
All research outputs
#1,377,724
of 25,083,571 outputs
Outputs from Annals of Surgical Oncology
#188
of 7,162 outputs
Outputs of similar age
#24,371
of 328,019 outputs
Outputs of similar age from Annals of Surgical Oncology
#6
of 105 outputs
Altmetric has tracked 25,083,571 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,162 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.