| Title |
Muscle MRI in severe Guillain–Barré syndrome with motor nerve inexcitability
|
|---|---|
| Published in |
Journal of Neurology, January 2013
|
| DOI | 10.1007/s00415-013-6845-y |
| Pubmed ID | |
| Authors |
María J. Sedano, Ana Canga, Carmen de Pablos, José M. Polo, José Berciano |
| Abstract |
We report on the clinical, electrophysiological, and lower-limb musculature MRI findings in a severe demyelinating Guillain-Barré syndrome (GBS) patient with follow-up over 6 months. After 3 weeks of tetraplegia and mechanical ventilation, there was progressive improvement until almost complete recovery. On day 4 after onset, electrophysiological study revealed absent F waves and widespread conduction block. On four further electrophysiological studies on days 12, 19, 45, and 150, there was marked and reversible slow down of motor conduction velocities in upper-limb nerves, and persistent inexcitability of lower-limb nerves. Mild signs of active denervation were recorded in calf and foot muscles as of day 45. On day 39, MRI T2-weighted fat-suppressed images showed patchy hypersignal of variable intensity involving pelvic, thigh, and calf muscles, which disappeared in a second imaging study on day 190; in this study T1-weighted images did not disclose muscle fatty atrophy. We conclude that in severe demyelinating GBS prolonged motor nerve inexcitability should not necessarily be taken as a predictor of poor prognosis, and that MRI is useful in assessing the topography and evolution of muscle denervation. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 3% |
| Unknown | 39 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 23% |
| Researcher | 6 | 15% |
| Student > Ph. D. Student | 5 | 13% |
| Other | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 9 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 33% |
| Agricultural and Biological Sciences | 3 | 8% |
| Neuroscience | 2 | 5% |
| Business, Management and Accounting | 2 | 5% |
| Immunology and Microbiology | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 12 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2022.
All research outputs
#7,687,335
of 23,390,392 outputs
Outputs from Journal of Neurology
#1,851
of 4,578 outputs
Outputs of similar age
#86,771
of 285,651 outputs
Outputs of similar age from Journal of Neurology
#19
of 46 outputs
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