| Title |
Mutation analysis of the SHFM1 gene in breast/ovarian cancer families
|
|---|---|
| Published in |
Journal of Cancer Research and Clinical Oncology, February 2013
|
| DOI | 10.1007/s00432-013-1385-5 |
| Pubmed ID | |
| Authors |
Sandra Bonache, Miguel de la Hoya, Sara Gutierrez-Enriquez, Anna Tenés, Miriam Masas, Judith Balmaña, Orland Diez |
| Abstract |
About 5-10 % of breast cancer is due to inherited disease predisposition. Currently known susceptibility genes such as BRCA1 and BRCA2 explain less than 25 % of familial aggregation of breast cancer, which suggests the involvement of additional genetic susceptibility. The SHFM1 [split hand/foot malformation (ectrodactyly) type 1] gene plays an important role in the regulation of gene transcription and cell proliferation and may be involved in the maintenance of genomic integrity. It is a potential candidate for being involved in heritable cancer susceptibility due to its biological function. The SHFM1 protein binds in mammalian cells to the longest conserved region of the BRCA2 protein and is required for BRCA2 stability and function, making a critical contribution to the BRCA2 function in mediating homologous recombination. Therefore, variants in the SHFM1 gene could affect the BRCA2 functionality and be associated with the familial breast/ovarian carcinogenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 28% |
| Student > Doctoral Student | 4 | 22% |
| Student > Ph. D. Student | 2 | 11% |
| Student > Bachelor | 2 | 11% |
| Student > Master | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 3 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 28% |
| Medicine and Dentistry | 5 | 28% |
| Agricultural and Biological Sciences | 3 | 17% |
| Physics and Astronomy | 1 | 6% |
| Unknown | 4 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2013.
All research outputs
#21,162,249
of 23,815,455 outputs
Outputs from Journal of Cancer Research and Clinical Oncology
#2,053
of 2,632 outputs
Outputs of similar age
#255,175
of 287,763 outputs
Outputs of similar age from Journal of Cancer Research and Clinical Oncology
#16
of 17 outputs
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