| Title |
Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process
|
|---|---|
| Published in |
AAPS PharmSciTech, January 2013
|
| DOI | 10.1208/s12249-013-9925-5 |
| Pubmed ID | |
| Authors |
Sarah Just, Gregor Toschkoff, Adrian Funke, Dejan Djuric, Georg Scharrer, Johannes Khinast, Klaus Knop, Peter Kleinebudde |
| Abstract |
Coating of solid dosage forms is an important unit operation in the pharmaceutical industry. In recent years, numerical simulations of drug manufacturing processes have been gaining interest as process analytical technology tools. The discrete element method (DEM) in particular is suitable to model tablet-coating processes. For the development of accurate simulations, information on the material properties of the tablets is required. In this study, the mechanical parameters Young's modulus, coefficient of restitution (CoR), and coefficients of friction (CoF) of gastrointestinal therapeutic systems (GITS) and of active-coated GITS were measured experimentally. The dynamic angle of repose of these tablets in a drum coater was investigated to revise the CoF. The resulting values were used as input data in DEM simulations to compare simulation and experiment. A mean value of Young's modulus of 31.9 MPa was determined by the uniaxial compression test. The CoR was found to be 0.78. For both tablet-steel and tablet-tablet friction, active-coated GITS showed a higher CoF compared with GITS. According to the values of the dynamic angle of repose, the CoF was adjusted to obtain consistent tablet motion in the simulation and in the experiment. On the basis of this experimental characterization, mechanical parameters are integrated into DEM simulation programs to perform numerical analysis of coating processes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Belgium | 1 | 1% |
| Unknown | 90 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 23% |
| Student > Master | 15 | 16% |
| Researcher | 14 | 15% |
| Student > Postgraduate | 7 | 8% |
| Student > Doctoral Student | 5 | 5% |
| Other | 15 | 16% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 32 | 34% |
| Chemical Engineering | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 11% |
| Medicine and Dentistry | 4 | 4% |
| Physics and Astronomy | 2 | 2% |
| Other | 10 | 11% |
| Unknown | 25 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2013.
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#18,327,422
of 22,694,633 outputs
Outputs from AAPS PharmSciTech
#1,222
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Outputs of similar age
#217,679
of 280,879 outputs
Outputs of similar age from AAPS PharmSciTech
#17
of 19 outputs
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