Title |
Stem cell metabolic and spectroscopic profiling
|
---|---|
Published in |
Trends in Biotechnology, February 2013
|
DOI | 10.1016/j.tibtech.2013.01.008 |
Pubmed ID | |
Authors |
Paul Ramm Sander, Peter Hau, Steffen Koch, Karin Schütze, Ulrich Bogdahn, Hans Robert Kalbitzer, Ludwig Aigner |
Abstract |
Stem cells offer great potential for regenerative medicine because they regenerate damaged tissue by cell replacement and/or by stimulating endogenous repair mechanisms. Although stem cells are defined by their functional properties, such as the potential to proliferate, to self-renew, and to differentiate into specific cell types, their identification based on the expression of specific markers remains vague. Here, profiles of stem cell metabolism might highlight stem cell function more than the expression of single genes/markers. Thus, systematic approaches including spectroscopy might yield insight into stem cell function, identity, and stemness. We review the findings gained by means of metabolic and spectroscopic profiling methodologies, for example, nuclear magnetic resonance spectroscopy (NMRS), mass spectrometry (MS), and Raman spectroscopy (RS), with a focus on neural stem cells and neurogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Mexico | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 2 | 1% |
Germany | 1 | <1% |
France | 1 | <1% |
Ireland | 1 | <1% |
Italy | 1 | <1% |
Czechia | 1 | <1% |
China | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Other | 0 | 0% |
Unknown | 142 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 42 | 28% |
Student > Ph. D. Student | 32 | 21% |
Professor | 16 | 11% |
Professor > Associate Professor | 13 | 9% |
Student > Master | 11 | 7% |
Other | 19 | 13% |
Unknown | 19 | 13% |
Readers by discipline | Count | As % |
---|---|---|
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Chemistry | 19 | 13% |
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Medicine and Dentistry | 14 | 9% |
Engineering | 9 | 6% |
Other | 19 | 13% |
Unknown | 24 | 16% |