Title |
Mendelian resistance to human norovirus infections
|
---|---|
Published in |
Seminars in Immunology, September 2006
|
DOI | 10.1016/j.smim.2006.07.009 |
Pubmed ID | |
Authors |
Jacques Le Pendu, Nathalie Ruvoën-Clouet, Elin Kindberg, Lennart Svensson |
Abstract |
Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the alpha1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host-pathogen co-evolution driven by carbohydrate-protein interactions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 4% |
Brazil | 1 | <1% |
Germany | 1 | <1% |
Afghanistan | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 121 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 27 | 21% |
Student > Ph. D. Student | 26 | 20% |
Student > Master | 17 | 13% |
Student > Bachelor | 10 | 8% |
Student > Postgraduate | 7 | 5% |
Other | 17 | 13% |
Unknown | 26 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 45 | 35% |
Biochemistry, Genetics and Molecular Biology | 18 | 14% |
Medicine and Dentistry | 14 | 11% |
Immunology and Microbiology | 7 | 5% |
Engineering | 4 | 3% |
Other | 13 | 10% |
Unknown | 29 | 22% |