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New Insights into Protein Hydroxylation and Its Important Role in Human Diseases

Overview of attention for article published in Biochimica et Biophysica Acta (BBA), September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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1 X user
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1 patent
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3 Wikipedia pages

Citations

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52 Dimensions

Readers on

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78 Mendeley
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Title
New Insights into Protein Hydroxylation and Its Important Role in Human Diseases
Published in
Biochimica et Biophysica Acta (BBA), September 2016
DOI 10.1016/j.bbcan.2016.09.004
Pubmed ID
Authors

Giada Zurlo, Jianping Guo, Mamoru Takada, Wenyi Wei, Qing Zhang

Abstract

Protein hydroxylation is a post-translational modification catalyzed by 2-oxoglutarate-dependent dioxygenases. The hydroxylation modification can take place on various amino acids, including but not limited to proline, lysine, asparagine, aspartate and histidine. A classical example of this modification is hypoxia inducible factor alpha (HIF-α) prolyl hydroxylation, which affects HIF-α protein stability via the Von-Hippel Lindau (VHL) tumor suppressor pathway, a Cullin 2-based E3 ligase adaptor protein frequently mutated in kidney cancer. In addition to protein stability regulation, protein hydroxylation may influence other post-translational modifications or the kinase activity of the modified protein (such as Akt and DYRK1A/B). In other cases, protein hydroxylation may alter protein-protein interaction and its downstream signaling events in vivo (such as OTUB1, MAPK6 and eEF2K). In this review, we highlight the recently identified protein hydroxylation targets and their pathophysiological roles, especially in cancer settings. Better understanding of protein hydroxylation will help identify novel therapeutic targets and their regulation mechanisms to foster development of more effective treatment strategies for various human cancers.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Unknown 76 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 27%
Student > Master 11 14%
Researcher 10 13%
Student > Bachelor 5 6%
Student > Doctoral Student 4 5%
Other 8 10%
Unknown 19 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 29 37%
Agricultural and Biological Sciences 10 13%
Chemistry 6 8%
Medicine and Dentistry 5 6%
Nursing and Health Professions 2 3%
Other 5 6%
Unknown 21 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2022.
All research outputs
#5,338,695
of 25,371,288 outputs
Outputs from Biochimica et Biophysica Acta (BBA)
#2,390
of 19,218 outputs
Outputs of similar age
#81,644
of 327,887 outputs
Outputs of similar age from Biochimica et Biophysica Acta (BBA)
#17
of 153 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,218 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,887 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.