Title |
Specific Expression of BMP2/4 Ortholog in Biomineralizing Tissues of Corals and Action on Mouse BMP Receptor
|
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Published in |
Marine Biotechnology, September 2008
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DOI | 10.1007/s10126-008-9141-6 |
Pubmed ID | |
Authors |
Didier Zoccola, Aurélie Moya, Guillaume E. Béranger, Eric Tambutté, Denis Allemand, Georges F. Carle, Sylvie Tambutté |
Abstract |
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily, and have been identified by their ability to induce bone formation in vertebrates. The biomineral-forming process, called biomineralization, is a widespread process, present in all kingdoms of living organisms and among which stony corals are one of the major groups of calcifying animals. Here, we report the presence of a BMP2/4 ortholog in eight species of adult corals. The synthesis of such a protein by the calcifying epithelium of corals suggests that coral BMP2/4 plays a role in skeletogenesis, making BMP the first common protein involved in biomineralization among Eumetazoans. In addition we show that recombinant coral BMP2/4 is able to inhibit human BMP2-induced osteoblastic differentiation in mesenchymal C2C12 cells. We suggest that this inhibition results from a competition between coral BMP2/4 and human BMP2, indicating conservation of binding affinity of BMP and its receptor during evolution from corals to vertebrates. Further studies are needed to understand interactions between coral BMP2/4 and its receptors, and, thus, the action of BMP2/4 in adult corals. |
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Geographical breakdown
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China | 1 | 1% |
Germany | 1 | 1% |
Taiwan | 1 | 1% |
Unknown | 81 | 94% |
Demographic breakdown
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Researcher | 20 | 23% |
Student > Master | 11 | 13% |
Professor | 6 | 7% |
Other | 4 | 5% |
Other | 11 | 13% |
Unknown | 9 | 10% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Earth and Planetary Sciences | 8 | 9% |
Environmental Science | 7 | 8% |
Chemistry | 3 | 3% |
Other | 4 | 5% |
Unknown | 10 | 12% |