| Title |
Physiology of the fasciculation potentials in amyotrophic lateral sclerosis: which motor units fasciculate?
|
|---|---|
| Published in |
The Journal of Physiological Sciences, September 2016
|
| DOI | 10.1007/s12576-016-0484-x |
| Pubmed ID | |
| Authors |
Mamede de Carvalho, Michael Swash |
| Abstract |
We set out to study whether in amyotrophic lateral sclerosis (ALS) fasciculation potentials (FPs) arise from the most excitable motor units (MUs). We studied 70 patients with ALS and 18 subjects with benign fasciculation syndrome (BFS). Of the 56 eligible ALS patients, 31 had signs of reinnervation in the right first dorsal interosseous muscle selected for study, and 25 did not. Two needle electrodes were placed in different MUs in each studied muscle. We defined the most excitable MU as that first activated by minimal voluntary contraction. In muscles without reinnervation, the recording site with most frequent FPs had a higher probability of showing the first recruited MU (p < 0.001). No significant difference was found in other patients or in BFS subjects. In very early affected muscles, fasciculating MUs are the most likely to be recruited volitionally. This probably represents hyperexcitability at lower motor neuronal level. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 21% |
| Student > Master | 4 | 17% |
| Student > Bachelor | 3 | 13% |
| Student > Ph. D. Student | 3 | 13% |
| Student > Postgraduate | 3 | 13% |
| Other | 4 | 17% |
| Unknown | 2 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 29% |
| Medicine and Dentistry | 6 | 25% |
| Engineering | 2 | 8% |
| Social Sciences | 1 | 4% |
| Psychology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2018.
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#21,476,880
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Outputs from The Journal of Physiological Sciences
#267
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#261,625
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Outputs of similar age from The Journal of Physiological Sciences
#11
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