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Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins

Overview of attention for article published in Modern Pathology, February 2013
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Title
Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins
Published in
Modern Pathology, February 2013
DOI 10.1038/modpathol.2012.232
Pubmed ID
Authors

Michael D Walsh, Margaret C Cummings, Sally-Ann Pearson, Mark Clendenning, Rhiannon J Walters, Belinda Nagler, John L Hopper, Mark A Jenkins, Graeme K Suthers, Jack Goldblatt, Kathy Tucker, Michael R Gattas, Julie L Arnold, Susan Parry, Finlay A Macrae, Michael A McGuckin, Joanne P Young, Daniel D Buchanan

Abstract

Mismatch repair-deficient breast cancers may be identified in Lynch syndrome mutation carriers, and have clinicopathological features in common with mismatch repair-deficient colorectal and endometrial cancers such as tumour-infiltrating lymphocytes and poor differentiation. Mismatch repair-deficient colorectal cancers frequently show mucinous differentiation associated with upregulation of chromosome 11 mucins. The aim of this study was to compare the protein expression of these mucins in mismatch repair-deficient and -proficient breast cancers. Cases of breast cancer (n=100) were identified from families where (1) both breast and colon cancer co-occurred and (2) families met either modified Amsterdam criteria or had at least one early-onset (<50 years) colorectal cancer. Tumour sections were stained for the epithelial mucins, MUC2, MUC5AC, MUC5B and MUC6, and the homeobox protein CDX2, a regulator of MUC2 expression. In all, 16 mismatch repair-deficient Lynch syndrome breast cancers and 84 non-Lynch breast cancers were assessed for altered mucin expression. No significant difference in the expression of MUC2, MUC5AC or MUC6 was observed between the mismatch repair-deficient and mismatch repair-proficient breast cancers; however, there was a trend for mismatch repair-deficient tumours to express high levels of MUC5B less frequently (P=0.07, OR=0.2 (0.0-1.0)). Co-expression of two or more gel-forming mucins was common. Ectopic expression of CDX2 was associated with expression of MUC2 (P=0.035, OR=8.7 (1.3-58.4)). Mismatch repair-deficient breast cancers do not show differential expression of the mucins genes on chromosome 11 when compared with mismatch repair-proficient breast cancers, in contrast with mismatch repair-deficient colorectal and endometrial cancers, which frequently have increased mucin protein expression when compared with their mismatch repair-proficient counterparts. In addition, ectopic CDX2 expression is positively associated with de novo MUC2 expression.

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The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 24%
Student > Ph. D. Student 4 14%
Other 3 10%
Student > Master 3 10%
Student > Bachelor 2 7%
Other 3 10%
Unknown 7 24%
Readers by discipline Count As %
Medicine and Dentistry 14 48%
Agricultural and Biological Sciences 3 10%
Computer Science 2 7%
Biochemistry, Genetics and Molecular Biology 1 3%
Social Sciences 1 3%
Other 1 3%
Unknown 7 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2013.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Modern Pathology
#2,979
of 3,283 outputs
Outputs of similar age
#229,842
of 291,207 outputs
Outputs of similar age from Modern Pathology
#36
of 42 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,283 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
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