| Title |
G-Quadruplexes: From Guanine Gels to Chemotherapeutics
|
|---|---|
| Published in |
Molecular Biotechnology, March 2011
|
| DOI | 10.1007/s12033-011-9395-5 |
| Pubmed ID | |
| Authors |
Tracy M. Bryan, Peter Baumann |
| Abstract |
G-quartets are square planar arrangements of four guanine bases, which can form extraordinarily stable stacks when present in nucleic acid sequences. Such G-quadruplex structures were long regarded as an in vitro phenomenon, but the widespread presence of suitable sequences in genomes and the identification of proteins that stabilize, modify or resolve these nucleic acid structures have provided circumstantial evidence for their physiological relevance. The therapeutic potential of small molecules that can stabilize or disrupt G-quadruplex structures has invigorated the field in recent years. Here we review some of the key observations that support biological functions for G-quadruplex DNA as well as the techniques and tools that have enabled researchers to probe these structures and their interactions with proteins and small molecules. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 150 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 48 | 32% |
| Student > Master | 22 | 14% |
| Researcher | 20 | 13% |
| Student > Bachelor | 18 | 12% |
| Professor > Associate Professor | 5 | 3% |
| Other | 9 | 6% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 38 | 25% |
| Biochemistry, Genetics and Molecular Biology | 32 | 21% |
| Agricultural and Biological Sciences | 32 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Computer Science | 3 | 2% |
| Other | 7 | 5% |
| Unknown | 32 | 21% |
Attention Score in Context
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#20,180,477
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Outputs from Molecular Biotechnology
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Outputs of similar age from Molecular Biotechnology
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