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TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons

Overview of attention for article published in Nature Genetics, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

news
9 news outlets
blogs
3 blogs
twitter
12 X users
wikipedia
2 Wikipedia pages

Citations

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69 Dimensions

Readers on

mendeley
104 Mendeley
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Title
TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons
Published in
Nature Genetics, September 2016
DOI 10.1038/ng.3681
Pubmed ID
Authors

Xavier Caubit, Paolo Gubellini, Joris Andrieux, Pierre L Roubertoux, Mehdi Metwaly, Bernard Jacq, Ahmed Fatmi, Laurence Had-Aissouni, Kenneth Y Kwan, Pascal Salin, Michèle Carlier, Agne Liedén, Eva Rudd, Marwan Shinawi, Catherine Vincent-Delorme, Jean-Marie Cuisset, Marie-Pierre Lemaitre, Fatimetou Abderrehamane, Bénédicte Duban, Jean-François Lemaitre, Adrian S Woolf, Detlef Bockenhauer, Dany Severac, Emeric Dubois, Ying Zhu, Nenad Sestan, Alistair N Garratt, Lydia Kerkerian-Le Goff, Laurent Fasano

Abstract

TSHZ3, which encodes a zinc-finger transcription factor, was recently positioned as a hub gene in a module of the genes with the highest expression in the developing human neocortex, but its functions remained unknown. Here we identify TSHZ3 as the critical region for a syndrome associated with heterozygous deletions at 19q12-q13.11, which includes autism spectrum disorder (ASD). In Tshz3-null mice, differentially expressed genes include layer-specific markers of cerebral cortical projection neurons (CPNs), and the human orthologs of these genes are strongly associated with ASD. Furthermore, mice heterozygous for Tshz3 show functional changes at synapses established by CPNs and exhibit core ASD-like behavioral abnormalities. These findings highlight essential roles for Tshz3 in CPN development and function, whose alterations can account for ASD in the newly defined TSHZ3 deletion syndrome.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 103 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 24%
Student > Ph. D. Student 20 19%
Student > Bachelor 14 13%
Student > Master 8 8%
Student > Doctoral Student 4 4%
Other 14 13%
Unknown 19 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 27%
Neuroscience 18 17%
Biochemistry, Genetics and Molecular Biology 13 13%
Medicine and Dentistry 10 10%
Psychology 7 7%
Other 4 4%
Unknown 24 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 86. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2022.
All research outputs
#479,229
of 24,892,887 outputs
Outputs from Nature Genetics
#986
of 7,488 outputs
Outputs of similar age
#9,325
of 329,749 outputs
Outputs of similar age from Nature Genetics
#29
of 77 outputs
Altmetric has tracked 24,892,887 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,488 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,749 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.