| Title |
Protein Quality Control System in Neurodegeneration: A Healing Company Hard to Beat but Failure is Fatal
|
|---|---|
| Published in |
Molecular Neurobiology, February 2013
|
| DOI | 10.1007/s12035-013-8411-0 |
| Pubmed ID | |
| Authors |
Deepak Chhangani, Amit Mishra |
| Abstract |
A common feature in most neurodegenerative diseases and aging is the progressive accumulation of damaged proteins. Proteins are essential for all crucial biological functions. Under some notorious conditions, proteins loss their three dimensional native conformations and are converted into disordered aggregated structures. Such changes rise into pathological conditions and eventually cause serious protein conformation disorders. Protein aggregation and inclusion bodies formation mediated multifactorial proteotoxic stress has been reported in the progression of Parkinson's disease (PD), Huntington's disease (HD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Prion disease. Ongoing studies have been remarkably informative in providing a systematic outlook for better understanding the concept and fundamentals of protein misfolding and aggregations. However, the precise role of protein quality control system and precursors of this mechanism remains elusive. In this review, we highlight recent insights and discuss emerging cytoprotective strategies of cellular protein quality control system implicated in protein deposition diseases. Our current review provides a clear, understandable framework of protein quality control system that may offer the more suitable therapeutic strategies for protein-associated diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Bolivia, Plurinational State of | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | 3% |
| United States | 1 | 2% |
| France | 1 | 2% |
| Unknown | 58 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 32% |
| Student > Master | 5 | 8% |
| Researcher | 4 | 6% |
| Student > Bachelor | 4 | 6% |
| Professor | 3 | 5% |
| Other | 10 | 16% |
| Unknown | 16 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 24% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Medicine and Dentistry | 6 | 10% |
| Neuroscience | 5 | 8% |
| Business, Management and Accounting | 2 | 3% |
| Other | 8 | 13% |
| Unknown | 17 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2013.
All research outputs
#13,680,290
of 22,694,633 outputs
Outputs from Molecular Neurobiology
#1,728
of 3,430 outputs
Outputs of similar age
#162,516
of 283,119 outputs
Outputs of similar age from Molecular Neurobiology
#8
of 18 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,430 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,119 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.