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LTP Requires a Unique Postsynaptic SNARE Fusion Machinery

Overview of attention for article published in Neuron, February 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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1 news outlet
blogs
1 blog
twitter
6 X users

Citations

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191 Dimensions

Readers on

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334 Mendeley
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Title
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
Published in
Neuron, February 2013
DOI 10.1016/j.neuron.2012.11.029
Pubmed ID
Authors

Sandra Jurado, Debanjan Goswami, Yingsha Zhang, Alfredo J. Miñano Molina, Thomas C. Südhof, Robert C. Malenka

Abstract

Membrane fusion during exocytosis is mediated by assemblies of SNARE (soluble NSF-attachment protein receptor) and SM (Sec1/Munc18-like) proteins. The SNARE/SM proteins involved in vesicle fusion during neurotransmitter release are well understood, whereas little is known about the protein machinery that mediates activity-dependent AMPA receptor (AMPAR) exocytosis during long-term potentiation (LTP). Using direct measurements of LTP in acute hippocampal slices and an in vitro LTP model of stimulated AMPAR exocytosis, we demonstrate that the Q-SNARE proteins syntaxin-3 and SNAP-47 are required for regulated AMPAR exocytosis during LTP but not for constitutive basal AMPAR exocytosis. In contrast, the R-SNARE protein synaptobrevin-2/VAMP2 contributes to both regulated and constitutive AMPAR exocytosis. Both the central complexin-binding and the N-terminal Munc18-binding sites of syntaxin-3 are essential for its postsynaptic role in LTP. Thus, postsynaptic exocytosis of AMPARs during LTP is mediated by a unique fusion machinery that is distinct from that used during presynaptic neurotransmitter release.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 334 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 2%
Japan 3 <1%
Switzerland 1 <1%
Chile 1 <1%
France 1 <1%
Netherlands 1 <1%
Austria 1 <1%
Finland 1 <1%
India 1 <1%
Other 5 1%
Unknown 312 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 79 24%
Researcher 66 20%
Student > Bachelor 36 11%
Student > Master 26 8%
Professor 18 5%
Other 56 17%
Unknown 53 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 143 43%
Neuroscience 77 23%
Medicine and Dentistry 18 5%
Biochemistry, Genetics and Molecular Biology 17 5%
Nursing and Health Professions 3 <1%
Other 18 5%
Unknown 58 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2018.
All research outputs
#2,073,783
of 25,374,917 outputs
Outputs from Neuron
#3,129
of 9,545 outputs
Outputs of similar age
#19,875
of 291,228 outputs
Outputs of similar age from Neuron
#37
of 99 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,545 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.2. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,228 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.