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Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution

Overview of attention for article published in American Journal of Respiratory & Critical Care Medicine, September 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Average Attention Score compared to outputs of the same age and source

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12 X users
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199 Mendeley
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Title
Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution
Published in
American Journal of Respiratory & Critical Care Medicine, September 2016
DOI 10.1164/rccm.201605-0997oc
Pubmed ID
Authors

Adel Boueiz, Sharon M Lutz, Michael H Cho, Craig P Hersh, Russell P Bowler, George R Washko, Eitan Halper-Stromberg, Per Bakke, Amund Gulsvik, Nan M Laird, Terri H Beaty, Harvey O Coxson, James D Crapo, Edwin K Silverman, Peter J Castaldi, Dawn L DeMeo

Abstract

Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe predominant emphysema has emerged as an important predictor of response to lung volume reduction surgery. Yet, aside from alpha-1 antitrypsin deficiency, the genetic determinants of emphysema distribution remain largely unknown. To identify the genetic influences of emphysema distribution in non-alpha-1 antitrypsin deficient smokers. 11,532 subjects with complete genotype and CT densitometry data in the COPDGene (non-Hispanic white and African American), ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints), and GenKOLS (Genetics of COPD, Norway) studies were analyzed. Two CT scan emphysema distribution measures (difference between upper third and lower third emphysema; ratio of upper third to lower third emphysema) were tested for genetic associations in all study subjects. Separate analyses in each study population were followed by a fixed effect meta-analysis. Single nucleotide polymorphism (SNP)-, gene-, and pathway-based approaches were used. In silico functional evaluation was also performed. We identified 5 loci associated with emphysema distribution at genome-wide significance. These loci included two previously reported associations with COPD susceptibility (4q31 near HHIP and 15q25 near CHRNA5) as well as three new associations near SOWAHB, TRAPPC9, and KIAA1462. Gene set analysis and in silico functional evaluation revealed pathways and cell types that may potentially contribute to the pathogenesis of emphysema distribution. This multi-cohort GWAS identified new genomic loci associated with differential emphysematous destruction throughout the lungs. These findings may point to new biological pathways upon which to expand our diagnostic and therapeutic approaches in COPD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 198 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 10%
Student > Ph. D. Student 5 3%
Student > Bachelor 4 2%
Professor 4 2%
Student > Postgraduate 3 2%
Other 9 5%
Unknown 155 78%
Readers by discipline Count As %
Medicine and Dentistry 16 8%
Biochemistry, Genetics and Molecular Biology 6 3%
Agricultural and Biological Sciences 5 3%
Nursing and Health Professions 2 1%
Immunology and Microbiology 2 1%
Other 6 3%
Unknown 162 81%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2017.
All research outputs
#6,239,802
of 25,377,790 outputs
Outputs from American Journal of Respiratory & Critical Care Medicine
#5,068
of 12,493 outputs
Outputs of similar age
#88,721
of 330,660 outputs
Outputs of similar age from American Journal of Respiratory & Critical Care Medicine
#102
of 191 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,493 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,660 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 191 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.