| Title |
AMP-activated protein kinase and its downstream transcriptional pathways
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, July 2010
|
| DOI | 10.1007/s00018-010-0454-z |
| Pubmed ID | |
| Authors |
Carles Cantó, Johan Auwerx |
| Abstract |
The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place through the acute modulation of key metabolic enzymes via direct phosphorylation, but also through a slower transcriptional adaptative response. The question of how AMPK regulates the expression of a number of gene sets, such as those related to mitochondrial biogenesis, energy production and oxidative protection, is only beginning to be elucidated, and still many questions remain to be answered. In this review we will try to integrate our current knowledge on how AMPK regulates transcription in muscle and liver, which will serve as examples to illustrate the major advances in the field and the key challenges ahead. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Kuwait | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 476 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | <1% |
| Brazil | 2 | <1% |
| United States | 2 | <1% |
| Norway | 1 | <1% |
| Ireland | 1 | <1% |
| Netherlands | 1 | <1% |
| Finland | 1 | <1% |
| Portugal | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 462 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 93 | 20% |
| Student > Ph. D. Student | 88 | 18% |
| Student > Master | 63 | 13% |
| Researcher | 58 | 12% |
| Student > Doctoral Student | 28 | 6% |
| Other | 63 | 13% |
| Unknown | 83 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 141 | 30% |
| Biochemistry, Genetics and Molecular Biology | 139 | 29% |
| Medicine and Dentistry | 38 | 8% |
| Nursing and Health Professions | 13 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 2% |
| Other | 41 | 9% |
| Unknown | 93 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2013.
All research outputs
#16,031,680
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,071
of 4,151 outputs
Outputs of similar age
#67,977
of 83,595 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#34
of 36 outputs
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